{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:35:36Z","timestamp":1783186536368,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["15243"],"award-info":[{"award-number":["15243"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003007","name":"Ministry of Scientific Research, Egypt","doi-asserted-by":"publisher","award":["15243"],"award-info":[{"award-number":["15243"]}],"id":[{"id":"10.13039\/501100003007","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> In Egypt, the prevalence of chronic hepatitis C (CHC) infection is 13.8% of whole population and about 80% of the patients with hepatocellular carcinoma have underling hepatitis C.<jats:italic> Aim.<\/jats:italic> This study was designed to assess the diagnostic value of plasma miR-122 and miR-21 in patients with CHC, genotype-4, to detect fibrosis progression versus noninvasive indices and their diagnostic value in detection of early stages of hepatocellular carcinoma (HCC).<jats:italic> Methodology.<\/jats:italic> A prospective study that included 180 patients, divided into 3 groups: healthy controls (group I), CHC patients (group II), and hepatitis C patients with HCC (group III); all cases were subjected to thorough clinical, radiological, and laboratory investigations. Selected biomarkers were evaluated and correlated with degree of liver damage. Results revealed that miR-122 followed by miR-21 had the highest efficiency in prediction of liver cell damage. Also, miR-21 was strongly correlated with vascular endothelial growth factor (VEGF) and alpha fetoprotein (<jats:italic>\u03b1<\/jats:italic>-FP) in HCC patients.<jats:italic> Conclusions.<\/jats:italic> Plasma miR-122 and miR-21 had strong correlation with degree fibrosis in HCV genotype-4 patients; consequently they can be considered as potential biomarker for early detection of hepatic fibrosis. Moreover, miR-21 can be used as a potential biomarker, for early detection of HCC combined with VEGF and <jats:italic>\u03b1<\/jats:italic>-FP.<\/jats:p>","DOI":"10.1155\/2017\/1806069","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T17:26:55Z","timestamp":1495560415000},"page":"1-10","source":"Crossref","is-referenced-by-count":24,"title":["Detection of MicroRNA in Hepatic Cirrhosis and Hepatocellular Carcinoma in Hepatitis C Genotype-4 in Egyptian Patients"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-3823","authenticated-orcid":true,"given":"Hala M.","family":"Demerdash","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology, Alexandria University Hospitals, Alexandria, Egypt"},{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy and Drug Manufacturing, Pharos University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend M.","family":"Hussien","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy and Drug Manufacturing, Pharos University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab","family":"Hassouna","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hepatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad A.","family":"Arida","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Surgical Intensive Care, Alexandria University Faculty of Medicine, Chamblion Street, Elazareeta, District-Zip Code 21526, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"2","key":"1","first-page":"S832","volume":"6","year":"2015","journal-title":"Journal of Hepatology"},{"key":"2","first-page":"361","volume":"120","year":"2009","journal-title":"Trans. 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