{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:03:19Z","timestamp":1791140599356,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Even though branchial cleft cysts are currently accepted as a congenital anomaly, there is often a long delay until clinical presentation; branchial cleft cysts classically appear in the second to fourth decade of life. Our observation of their occurrence in three pregnant women encouraged us to contemplate a possible hormonal influence.<jats:italic> Methods<\/jats:italic>. Immunohistological analysis was performed for the evaluation of the estrogen receptor alpha (ER<jats:italic>\u03b1<\/jats:italic>) in paraffin-embedded tissue specimens of 16 patients with a diagnosis of branchial cleft cyst, with three of them being pregnant.<jats:italic> Results<\/jats:italic>. Expression of ER<jats:italic>\u03b1<\/jats:italic> was detected within epithelial cells only in branchial cleft cysts in pregnant females; moreover, higher growth fractions (Ki-67\/Mib1) were found.<jats:italic> Conclusion<\/jats:italic>. The fact that the estrogen receptor was expressed only in pregnant women, in contrast to 13 investigated cases, may suggest that the high level of estrogen in pregnancy is a possible explanation for the spontaneous growth of branchial cleft cysts.<\/jats:p>","DOI":"10.1155\/2017\/1807056","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T18:30:51Z","timestamp":1513708251000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Possible Estrogen Dependency in the Pathogenesis of Branchial Cleft Cysts"],"prefix":"10.1155","volume":"2017","author":[{"given":"Jan D.","family":"Raguse","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, 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