{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T05:47:43Z","timestamp":1745819263210,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Shigellosis is an acute infectious disease characterized as severe bloody diarrhea (dysentery) and is accountable for a significant burden of morbidity and mortality especially in children under the age of 5 years. Antimicrobial therapy is required in the cases of severe dysentery associated with<jats:italic> Shigella<\/jats:italic>. However, emergence of multidrug resistant (MDR) strains of<jats:italic> Shigella<\/jats:italic> spp. over the last two decades has restricted the use of common therapeutic antimicrobials. In MDR strains, the third-generation cephalosporins have been used for the treatment, but, unfortunately, emerging reports of enzyme mediated <jats:italic>\u03b2<\/jats:italic>-lactam resistance among<jats:italic> Shigella<\/jats:italic> isolates from various parts of the world have greatly compromised the therapy of pediatric dysentery. In Nepal, drug resistant strains of<jats:italic> Shigella<\/jats:italic> spp. have been reported, but MDR and extended spectrum <jats:italic>\u03b2<\/jats:italic>-lactamase (ESBL) producing strains were previously unknown. Here, we report two<jats:italic> Shigella flexneri<\/jats:italic> isolates harboring ESBL genotype-CTX-M associated with acute dysentery in two siblings which were presented and treated in a tertiary care teaching hospital of Kathmandu, Nepal.<\/jats:p>","DOI":"10.1155\/2017\/1862320","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T16:03:43Z","timestamp":1487693023000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Shigellosis Caused by CTX-M Type ESBL Producing<i> Shigella flexneri<\/i> in Two Siblings of Rural Nepal: First Case Report from the Country"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3228-9908","authenticated-orcid":true,"given":"Narayan Prasad","family":"Parajuli","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Services, Manmohan Memorial Medical College and Teaching Hospital, Kathmandu, Nepal"},{"name":"Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govardhan","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal"},{"name":"Kathmandu Center for Genomics and Research Laboratory (KCGRL), Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashu Dev","family":"Pardhe","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotsna","family":"Shakya","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8627-9150","authenticated-orcid":true,"given":"Anjeela","family":"Bhetwal","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreena","family":"Shakya","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan","family":"Pandit","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumesh Shreekhanda","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Manmohan 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