{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:39:44Z","timestamp":1780526384596,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Directorate of Research, Publication and Technology Transfer of Jigjiga University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>.<jats:italic> Haemonchus contortus, <\/jats:italic>the causative agent of Haemonchosis, is the most economically important parasite in small ruminant production. Control with chemotherapy has not been successful due to rapid emergence of drug-resistant strains. There is a continuous search for alternative leads particularly from plants. The study aimed to evaluate the anthelmintic activity of crude methanolic extracts of leaves of<jats:italic> Schinus molle <\/jats:italic>and aerial parts of<jats:italic> Cissus quadrangularis<\/jats:italic> against<jats:italic> H. contortus. Methods<\/jats:italic>. Adult motility test and egg hatching inhibition assay were employed to investigate the<jats:italic> in vitro <\/jats:italic>adulticidal and egg hatching inhibitory effects of the extracts.<jats:italic> Results<\/jats:italic>. Higher concentrations of the extracts (10 and 5\u2009mg\/ml) had a significantly superior adulticidal activity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) compared to the negative control and lower concentration levels, which was comparable to albendazole<jats:italic>. <\/jats:italic>Similarly, the relative egg hatch inhibition efficacy of<jats:italic> S. molle <\/jats:italic>and<jats:italic> C. quadrangularis <\/jats:italic>extracts indicated a maximum of 96% and 88% egg hatch inhibition, respectively, within the 48\u2009hrs of exposure at 1\u2009mg\/ml.<jats:italic> Conclusion<\/jats:italic>. The current study evidenced that the crude methanolic extracts of the plants have promising adulticidal and egg hatching inhibitory effects against<jats:italic> H. contortus<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2017\/1905987","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T18:30:57Z","timestamp":1513708257000},"page":"1-6","source":"Crossref","is-referenced-by-count":39,"title":["<i>In Vitro<\/i> Anthelmintic Activity of Crude Extracts of Aerial Parts of<i> Cissus quadrangularis<\/i> L. and Leaves of<i> Schinus molle<\/i> L. against<i> Haemonchus contortus<\/i>"],"prefix":"10.1155","volume":"2017","author":[{"given":"Selamawit","family":"Zenebe","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Studies, College of Veterinary Medicine, Jigjiga University, Jigjiga, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teka","family":"Feyera","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Studies, College of Veterinary Medicine, Jigjiga University, Jigjiga, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1538-9322","authenticated-orcid":true,"given":"Solomon","family":"Assefa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2004.07.012"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/srep26200"},{"key":"3","year":"2002"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(90)90199-W"},{"key":"6","first-page":"115","volume":"16","year":"2002","journal-title":"Veterinary Parasitology"},{"key":"7","first-page":"94","volume":"4","year":"2006","journal-title":"International Journal of Applied Research in Veterinary Medicine"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4172\/2157-7579.S10-001"},{"key":"9","first-page":"109","volume":"5","year":"2011","journal-title":"Journal Cell and Animal Biology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-4488(00)00163-2"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(03)00040-2"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.07.051"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1149-6"},{"issue":"3","key":"14","first-page":"188","volume":"31","year":"2017","journal-title":"Ethiopian Journal of Health Developmentvol"},{"key":"16","year":"1989"},{"key":"17","year":"1993"},{"key":"18","year":"1982"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(92)90141-U"},{"key":"20","first-page":"33","volume":"5","year":"1971","journal-title":"Indian Journal Animal Research"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.02.020"},{"key":"22","year":"2005"},{"issue":"6","key":"23","first-page":"15","volume":"3","year":"2015","journal-title":"International Journal of Research in Applied Natural and Social Sciences"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2007.03.003"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.03.028"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.11.004"},{"issue":"2","key":"27","first-page":"6","volume":"2","year":"2012","journal-title":"Jam online"},{"key":"28","year":"2002"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2008000400013"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2010.03.032"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(05)80005-X"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/1905987.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/1905987.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/1905987.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T18:31:00Z","timestamp":1513708260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/1905987\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":29,"alternative-id":["1905987","1905987"],"URL":"https:\/\/doi.org\/10.1155\/2017\/1905987","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}