{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:36:48Z","timestamp":1792255008856,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004530","name":"Universiti Putra Malaysia","doi-asserted-by":"publisher","award":["04-02-1756 RU"],"award-info":[{"award-number":["04-02-1756 RU"]}],"id":[{"id":"10.13039\/501100004530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>The in vivo antibacterial and burn wound healing potency of Persian shallot bulbs (<jats:italic>Allium stipitatum<\/jats:italic>) were explored in a mice burn model infected with methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA). Hexane (ASHE) and dichloromethane (ASDE) extracts were tested. Female BALB\/c mice were inflicted with third\u2010degree thermal injury followed by infection with MRSA. ASHE and ASDE formulated with simple ointment base (SOB) at concentrations of 1%, 2%, and 5% (w\/w) were topically applied to burn wounds twice a day for 20 days. Silver sulfadiazine (1%) served as drug positive control. Microbiological analysis was carried out on 1, 2, 3, 4, and 5 days postwounding (dpw) and histopathological analysis at the end of the experiment (20\u2009dpw). Both ointments demonstrated strong antibacterial activity with complete elimination of MRSA at 48\u201372\u2009h after infection. The rate of wound contraction was higher (95\u2013100%) in mice groups treated with ASHE and ASDE ointments after 15\u2009dpw. Histological analysis revealed significant increase (<jats:italic>p<\/jats:italic> &lt; 0.05) in epithelialization and collagenation in treated groups. The ASHE and ASDE were found to be relatively noncytotoxic and safe to Vero cell line (383.4\u2009<jats:italic>\u03bc<\/jats:italic>g\u2009mL<jats:sup>\u22121<\/jats:sup>; 390.6\u2009<jats:italic>\u03bc<\/jats:italic>g\u2009mL<jats:sup>\u22121<\/jats:sup>), suggesting the extracts as safe topical antibacterial as well as promising alternatives in managing thermal injuries.<\/jats:p>","DOI":"10.1155\/2017\/1914732","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T21:00:28Z","timestamp":1487797228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<i>Allium stipitatum<\/i> Extract Exhibits In Vivo Antibacterial Activity against Methicillin\u2010Resistant <i>Staphylococcus aureus<\/i> and Accelerates Burn Wound Healing in a Full\u2010Thickness Murine Burn Model"],"prefix":"10.1155","volume":"2017","author":[{"given":"Arunkumar","family":"Karunanidhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8484-7166","authenticated-orcid":false,"given":"Ehsanollah","family":"Ghaznavi-Rad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakayatri","family":"Jeevajothi Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7888-9004","authenticated-orcid":false,"given":"Yusuf","family":"Abba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex van","family":"Belkum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-8335","authenticated-orcid":false,"given":"Vasanthakumari","family":"Neela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.2.403-434.2006"},{"key":"e_1_2_8_2_2","volume-title":"WHO Reports. 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