{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:13:09Z","timestamp":1771002789494,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alcon Research, Ltd., Fort Worth, Texas, USA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the efficacy and tolerability of travoprost 0.004%\/timolol 0.5% fixed-dose combination (TTFC) in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT) inadequately controlled on beta-blocker monotherapy.<jats:italic>Methods<\/jats:italic>. In this phase IV, open-label study, 156 patients on beta-blocker monotherapy with mean intraocular pressure (IOP) between 18 and 32\u2009mmHg were randomized (no washout period) to receive TTFC for 8 weeks (TTFC group) or to continue beta-blocker monotherapy for 4 weeks followed by TTFC for the remaining 4 weeks (beta-blocker group).<jats:italic>Results<\/jats:italic>. The mean IOP (\u00b1standard deviation) at baseline in the TTFC and beta-blocker groups was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn fontstyle=\"italic\">22.5<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">2.5<\/mml:mn><\/mml:math>\u2009mmHg and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn fontstyle=\"italic\">22.2<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">2.3<\/mml:mn><\/mml:math>\u2009mmHg, respectively, and at weeks 4 and 8, was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn fontstyle=\"italic\">16.7<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">3.1<\/mml:mn><\/mml:math>\u2009mmHg and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mn fontstyle=\"italic\">16.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">3.1<\/mml:mn><\/mml:math>\u2009mmHg, respectively, in TTFC group and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mn fontstyle=\"italic\">21.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">3.1<\/mml:mn><\/mml:math>\u2009mmHg and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mn fontstyle=\"italic\">16.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">2.8<\/mml:mn><\/mml:math>\u2009mmHg, respectively, in the beta-blocker group. There was a significant least squares mean difference between TTFC and beta-blocker in 8 a.m. IOP at week 4 (\u22124.6\u2009mmHg; one-sided 95% confidence interval [\u2212inf, \u22123.9];<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.0001<\/mml:mn><\/mml:math>[primary endpoint]); the upper bound of the 95% confidence interval was within the prespecified limit (&lt;0). Both treatments were well tolerated.<jats:italic>Conclusion<\/jats:italic>. Superior IOP control was achieved with TTFC in patients with OAG or OHT previously uncontrolled with beta-blockers. No new safety findings were identified. This trial is registered with ClinicalTrials.gov<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02003391\">NCT02003391<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2017\/1917570","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T16:07:06Z","timestamp":1485187626000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and Tolerability of Travoprost 0.004<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi mathvariant=\"normal\">%<\/mml:mi><\/mml:mrow><\/mml:math>\/Timolol 0.5<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi mathvariant=\"normal\">%<\/mml:mi><\/mml:mrow><\/mml:math>Fixed-Dose Combination for the Treatment of Primary Open-Angle Glaucoma or Ocular Hypertension Inadequately Controlled with Beta-Blocker Monotherapy"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4657-286X","authenticated-orcid":true,"given":"Simon Fabian","family":"Lerner","sequence":"first","affiliation":[{"name":"Organizaci\u00f3n Medica de Investigaci\u00f3n (OMI), Buenos Aires, Argentina"},{"name":"Fundaci\u00f3n para el Estudio del Glaucoma, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas A.","family":"Hubatsch","sequence":"additional","affiliation":[{"name":"Alcon Research, Ltd., Fort Worth, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeriy","family":"Erichev","sequence":"additional","affiliation":[{"name":"Research Institute of Eye Diseases, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Paczka","sequence":"additional","affiliation":[{"name":"Instituto de Oftalmologia y Ciencias Visuales, CUCS, Universidad de Guadalajara, Guadalajara, JAL, Mexico"},{"name":"Unidad de Diagnostico Temprano del Glaucoma, Global Glaucoma Institute Occidente, Guadalajara, JAL, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy V.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Sydney Medical School, University of Sydney, Sydney, NSW, Australia"},{"name":"Vision Eye Institute, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","year":"2014"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2011.563733"},{"issue":"4","key":"3","year":"2007","journal-title":"Cochrane Database of Systematic 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