{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:59:56Z","timestamp":1783720796748,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate corneal transparency following accelerated collagen cross-linking (ACXL) in pediatric keratoconus.<jats:italic>Design<\/jats:italic>. A prospective interventional case series.<jats:italic>Methods<\/jats:italic>. This study included 47 eyes (25 patients), aged 9\u201314 years, with documented progressive keratoconus. After applying 0.1% riboflavin drops, ACXL was performed. Assessment included corrected distance visual acuity (CDVA), uncorrected visual acuity (UCVA), corneal haze, and corneal densitometry in grayscale units (GSU).<jats:italic>Result<\/jats:italic>. The mean baseline and corneal densitometry peaked at 3 months post-ACXL while central and posterior densitometry showed a statistically significant increase (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) and peaked at 8 months postoperatively. By 12 months, densitometry in all corneal layers (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>\u2265<\/mml:mo><mml:mn>0.99<\/mml:mn><\/mml:math>) and concentric zones (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>\u2265<\/mml:mo><mml:mn>0.97<\/mml:mn><\/mml:math>) reached near baseline values. Slit-lamp graded haze peaked at 1 month to 1.82\u2009\u00b1\u20090.65 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) and declined to near baseline at 12 months (0.39\u2009\u00b1\u20090.58). There was a statistically significant increase in the mean UCVA and CDVA at 12 months.<jats:italic>Conclusion<\/jats:italic>. Total and anterior corneal densitometry peaked after 3 months, while central and posterior densitometry peaked after 8 months. Maximum haze was at 1 month post-ACXL. All corneal layers, concentric zone densitometry and haze reached near baseline values after 1 year. Scheimpflug densitometry showed weak correlation with CDVA over the 12-month follow-up period (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>0.193<\/mml:mn><\/mml:math>).<\/jats:p>","DOI":"10.1155\/2017\/1923161","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T23:31:08Z","timestamp":1514763068000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["Primary Outcomes of Accelerated Epithelium-Off Corneal Cross-Linking in Progressive Keratoconus in Children: A 1-Year Prospective Study"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-4343","authenticated-orcid":true,"given":"Sherif A.","family":"Eissa","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Kasr Alainy, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1692-6188","authenticated-orcid":true,"given":"Nashwa","family":"Badr Eldin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Kasr Alainy, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-6813","authenticated-orcid":true,"given":"Ashraf Ahmed","family":"Nossair","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Kasr Alainy, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael Ahmed","family":"Ewais","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Kasr Alainy, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.06.067"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.11.036"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.116070"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000702"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000819"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.07.043"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000105827.85025.7f"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200401000-00008"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9385"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0b013e3182729df0"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.116075"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2013.834497"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.09.035"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.03.050"},{"issue":"7","key":"16","doi-asserted-by":"crossref","first-page":"S720","DOI":"10.3928\/1081597X-20080901-15","volume":"24","year":"2008","journal-title":"Journal of Refractive Surgery"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31817f815a"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31313-3"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1098\/rspl.1862.0069"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.2.7.6"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20121011-05"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/icl.0000000000000255"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.01.009"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11387"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20121011-08"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2012.06.002"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2015.02.010"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.03.026"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/894095"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20141120-01"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20150820-07"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20121011-06"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000934"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31826672e2"},{"issue":"5","key":"35","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3928\/1081-597X-20000901-04","volume":"16","year":"2000","journal-title":"Journal of Refractive Surgery"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/1923161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/1923161.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/1923161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T17:03:44Z","timestamp":1660237424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2017\/1923161\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":35,"alternative-id":["1923161","1923161"],"URL":"https:\/\/doi.org\/10.1155\/2017\/1923161","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}