{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:37:11Z","timestamp":1740145031396,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wyzszego","doi-asserted-by":"publisher","award":["N N 402 177934"],"award-info":[{"award-number":["N N 402 177934"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PPAR Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Activation of PPARs may be involved in the development of heart failure (HF). We evaluated the relationship between expression of PPAR<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>in the myocardium during coronary artery bypass grafting (CABG) and exercise tolerance initially and during follow-up. 6-minute walking test was performed before CABG, after 1, 12, 24 months. Patients were divided into two groups (HF and non-HF) based on left ventricular ejection fraction and plasma proBNP level. After CABG, 67% of patients developed HF. The mean distance 1 month after CABG in HF was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn mathvariant=\"normal\">397<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn mathvariant=\"normal\">85<\/mml:mn><\/mml:math>\u2009m versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn fontstyle=\"italic\">420<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">93<\/mml:mn><\/mml:math>\u2009m in non-HF. PPAR<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>mRNA expression was similar in both HF and non-HF groups. 6MWT distance 1 month after CABG was inversely correlated with PPAR<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>level only in HF group. Higher PPAR<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>expression was related to smaller LVEF change between 1 month and 1 year (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>R<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.18<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn mathvariant=\"normal\">5<\/mml:mn><\/mml:math>), especially in patients with HF. Higher initial levels of IL-6 in HF patients were correlated with longer distance in 6MWT one month after surgery and lower PPAR<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>expression. PPAR<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>expression is not related to LVEF before CABG and higher PPAR<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>expression in the myocardium of patients who are developing HF following CABG may have some protecting effect.<\/jats:p>","DOI":"10.1155\/2017\/1924907","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T17:02:34Z","timestamp":1506618154000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Myocardial Expression of PPAR<i>\u03b3<\/i>and Exercise Capacity in Patients after Coronary Artery Bypass Surgery"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0951-2139","authenticated-orcid":true,"given":"Izabela","family":"Wojtkowska","sequence":"first","affiliation":[{"name":"Institute of Cardiology, Intensive Cardiac Therapy Clinic, Alpejska St. 42, 04-628 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz A.","family":"Bonda","sequence":"additional","affiliation":[{"name":"Department of General and Experimental Pathology, Medical University of Bialystok, Mickiewicza St. 2c, 15-222 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Wolszakiewicz","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Department of Cardiac Rehabilitation and Noninvasive Electrocardiology, Alpejska St. 42, 04-628 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Osak","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Department of Cardiac Rehabilitation and Noninvasive Electrocardiology, Alpejska St. 42, 04-628 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Tysarowski","sequence":"additional","affiliation":[{"name":"Institute of Oncology, Department of Molecular and Translational Oncology, Wawelska St. 15B, 02-034 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Seliga","sequence":"additional","affiliation":[{"name":"Institute of Oncology, Department of Molecular and Translational Oncology, Wawelska St. 15B, 02-034 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz A.","family":"Siedlecki","sequence":"additional","affiliation":[{"name":"Institute of Oncology, Department of Molecular and 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