{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:21:54Z","timestamp":1772857314739,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005279","name":"UFPI","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005279","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The<jats:italic>Protium heptaphyllum<\/jats:italic>species, also known as Alm\u00e9cega, produces an oily resin, used in folk medicine as an analgesic and anti-inflammatory agent, in healing, and as an expectorant, which is rich in pentacyclic triterpenes and essential oils. In this study, the essential oil obtained by hydrodistillation of Alm\u00e9cega\u2019s resin was analyzed by gas chromatography-triple quadrupole mass spectrometry and evaluated for chemical composition and vasorelaxant activity in rat superior mesenteric artery. The main constituents determined by gas chromatography-triple quadrupole mass spectrometry were limonene,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><\/mml:mrow><\/mml:math>-cineole, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>o<\/mml:mi><\/mml:mrow><\/mml:math>-cymene. In intact rings precontracted with phenylephrine (Phe 1\u2009<jats:italic>\u03bc<\/jats:italic>M), EOPh (3\u2013750\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) induced relaxation, and the essential oil had a concentration-dependent vasorelaxant effect, without involvement of endothelial mediators.<\/jats:p>","DOI":"10.1155\/2017\/1928171","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T21:01:44Z","timestamp":1504126904000},"page":"1-6","source":"Crossref","is-referenced-by-count":14,"title":["Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil from<i>Protium heptaphyllum<\/i>(Aubl.) 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