{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:06:06Z","timestamp":1759939566368,"version":"3.37.3"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. We explored the potential association between antipsychotics and QT\/QTc duration changes in hospitalized male patients with psychotic disorders.<jats:italic> Methods<\/jats:italic>. The chart review was conducted on 184 male patients hospitalized between 2013 and 2015 at the Psychiatric Clinic of Pisa, Italy. Patients who were treated with one atypical antipsychotic at the time of the ECG recording were 109\/184 (59.2%). QT\/QTc were compared considering the atypical antipsychotic received.<jats:italic> Results<\/jats:italic>. 96.3% (<jats:italic>n<\/jats:italic> = 105\/109) of the sample showed QTc values \u2264 430\u2009ms; 4 patients (3.7%) had QTc values between 430 and 450\u2009msec (2 with paliperidone, 1 with risperidone, and 1 with olanzapine). The mean QT duration of the overall sample was 368.0 \u00b1 28.0 and the mean QTc 400.1 \u00b1 17.8. QTc values did not reveal statistically significant differences. QT values were significantly different (chi-square = 17.3; df = 5;<jats:italic> p<\/jats:italic> = .004). Statistically significant differences between aripiprazole and paliperidone (349.0 \u00b1 28.3 versus 390.5 \u00b1 29.8;<jats:italic> p<\/jats:italic> = .002) and between clozapine and paliperidone (361.1 \u00b1 22.43 versus 390.5 \u00b1 29.8;<jats:italic> p<\/jats:italic> = .033) were found.<jats:italic> Conclusions<\/jats:italic>. Aripiprazole was the least interfering neuroleptic with QT\/QTc. Paliperidone was the atypical neuroleptic with the most relevant difference with aripiprazole, but only on QT.<\/jats:p>","DOI":"10.1155\/2017\/1951628","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T17:02:23Z","timestamp":1499878943000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["QT and QTc in Male Patients with Psychotic Disorders Treated with Atypical Neuroleptics"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-9927","authenticated-orcid":true,"given":"Mario","family":"Miniati","sequence":"first","affiliation":[{"name":"Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-888X","authenticated-orcid":true,"given":"Marly","family":"Simoncini","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Vanelli","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Massimetti","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Carmassi","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Dell\u2019Osso","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2012.11.001"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/273060"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.12.1293"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.016"},{"journal-title":"Journal of Clinical Psychiatry","first-page":"20","year":"2002","key":"6"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200262110-00006"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(00)00152-9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0032-z"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2017\/1951628.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2017\/1951628.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2017\/1951628.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T17:02:23Z","timestamp":1499878943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/tswj\/2017\/1951628\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":9,"alternative-id":["1951628","1951628"],"URL":"https:\/\/doi.org\/10.1155\/2017\/1951628","relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"type":"print","value":"2356-6140"},{"type":"electronic","value":"1537-744X"}],"subject":[],"published":{"date-parts":[[2017]]}}}