{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:27:29Z","timestamp":1767652049266,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Syphilis has been coined \u201cthe great imitator\u201d due to its extreme heterogeneity of presentation and mimicry of other conditions. Therefore, it is essential that physicians be familiar with the full spectrum of its manifestations. Syphilis may also lead to oral lesions that, occasionally, are unaccompanied by concomitant tegumentary findings. Such patients will pose unique diagnostic challenges. We report the case of a 45-year-old HIV-infected male patient in whom secondary syphilis presented with burning mouth and dysgeusia that progressed to glossodynia and odynophagia. Examination revealed painful, shallow erosions on the posterior aspect of the tongue, in a pattern of<jats:italic> plaques en prairie fauch\u00e9e<\/jats:italic>. A painful split papule (<jats:italic>fausse perl\u00e8che <\/jats:italic>or false angular cheilitis) was also present in the left commissure. There were no cutaneous lesions. The oral lesions were considered highly suggestive of secondary syphilis. A novel VDRL assay (which was previously negative) yielded a titer of 1\/128. Complete clinical remission was rapidly achieved after initiation of penicillin therapy. A comprehensive review of the literature on oral manifestations of syphilis is offered.<\/jats:p>","DOI":"10.1155\/2017\/1980798","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T17:02:49Z","timestamp":1499878969000},"page":"1-5","source":"Crossref","is-referenced-by-count":14,"title":["Secondary Syphilis Presenting as Glossodynia,<i> Plaques en Prairie Fauch\u00e9e<\/i>, and a Split Papule at the Oral Commissure: Case Report and Review"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6386-666X","authenticated-orcid":true,"given":"Walter de Araujo","family":"Eyer-Silva","sequence":"first","affiliation":[{"name":"Hospital Universit\u00e1rio Gaffr\u00e9e e Guinle, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alessandra Leite","family":"Freire","sequence":"additional","affiliation":[{"name":"Programa Municipal de HIV\/AIDS de Miracema, Posto de Sa\u00fade Dr. Irineu Sodr\u00e9, Av. Nilo Pe\u00e7anha 59, 28460-000 Miracema, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cec\u00edlia Angelina","family":"Horta-Araujo","sequence":"additional","affiliation":[{"name":"Programa Municipal de HIV\/AIDS de Miracema, Posto de Sa\u00fade Dr. Irineu Sodr\u00e9, Av. Nilo Pe\u00e7anha 59, 28460-000 Miracema, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-2857","authenticated-orcid":true,"given":"Guilherme","family":"Almeida Rosa da Silva","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Gaffr\u00e9e e Guinle, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Francisco da Cunha Pinto","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Gaffr\u00e9e e Guinle, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Raphael de Almeida Ferry","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Gaffr\u00e9e e Guinle, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1016\/0030-4220(67)90484-7"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1590\/S1807-59322006000200012"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1016\/j.oooo.2012.04.028"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1111\/j.1346-8138.1995.tb03341.x"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1016\/0030-4220(84)90363-3"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1097\/00007435-198510000-00014"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1001\/archfami.5.7.379"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1067\/S0190-9622(03)00484-5"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1017\/S002221510600096X"},{"issue":"2, article 23","key":"10","volume":"14","year":"2008","journal-title":"Dermatology Online Journal"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1155\/2016\/1607583"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1155\/2016\/6295920"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1016\/0030-4220(78)90034-8"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1016\/j.bjid.2016.03.008"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1016\/S1079-2104(96)80070-9"},{"issue":"10","key":"16","first-page":"683","volume":"25","year":"2002","journal-title":"Chang Gung Medical Journal"},{"issue":"1","key":"17","first-page":"33","volume":"9","year":"2004","journal-title":"Medicina Oral"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1155\/2013\/892427"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.1016\/j.joms.2013.07.015"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1016\/j.oooo.2015.09.022"},{"volume-title":"Syphilis","year":"2012","key":"21"},{"volume-title":"Sexually Tranmitted Infections","year":"2012","key":"22"},{"doi-asserted-by":"publisher","key":"23","DOI":"10.1111\/odi.12058"},{"doi-asserted-by":"publisher","key":"24","DOI":"10.1016\/j.ijom.2004.01.029"},{"doi-asserted-by":"publisher","key":"25","DOI":"10.1111\/j.1365-2230.2010.03879.x"},{"doi-asserted-by":"publisher","key":"26","DOI":"10.1111\/ijd.13206"},{"doi-asserted-by":"publisher","key":"27","DOI":"10.1002\/bjs.18004720517"},{"doi-asserted-by":"publisher","key":"28","DOI":"10.1016\/0030-4220(70)90360-9"},{"doi-asserted-by":"publisher","key":"29","DOI":"10.1016\/j.tmaid.2004.02.010"},{"doi-asserted-by":"publisher","key":"30","DOI":"10.1016\/j.jinf.2008.06.006"},{"doi-asserted-by":"publisher","key":"31","DOI":"10.1136\/jcp.2010.077586"},{"doi-asserted-by":"publisher","key":"32","DOI":"10.1016\/0030-4220(93)90431-3"},{"doi-asserted-by":"publisher","key":"33","DOI":"10.1016\/j.anndiagpath.2015.01.003"},{"doi-asserted-by":"publisher","key":"34","DOI":"10.1111\/j.1468-3083.2008.02926.x"},{"doi-asserted-by":"publisher","key":"35","DOI":"10.1016\/j.tripleo.2009.05.013"},{"doi-asserted-by":"publisher","key":"36","DOI":"10.1016\/j.ijid.2015.04.007"},{"doi-asserted-by":"publisher","key":"37","DOI":"10.1016\/j.jaad.2005.08.043"},{"doi-asserted-by":"publisher","key":"38","DOI":"10.1016\/j.ijom.2014.09.014"},{"doi-asserted-by":"publisher","key":"39","DOI":"10.1111\/ger.12047"},{"doi-asserted-by":"publisher","key":"40","DOI":"10.4103\/1305-7456.163219"},{"year":"2011","key":"41"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2017\/1980798.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2017\/1980798.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2017\/1980798.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T17:02:49Z","timestamp":1499878969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crim\/2017\/1980798\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":41,"alternative-id":["1980798","1980798"],"URL":"https:\/\/doi.org\/10.1155\/2017\/1980798","relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"type":"print","value":"1687-9627"},{"type":"electronic","value":"1687-9635"}],"subject":[],"published":{"date-parts":[[2017]]}}}