{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:47:23Z","timestamp":1783334843674,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T00:00:00Z","timestamp":1511654400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31200868"],"award-info":[{"award-number":["31200868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017,11,26]]},"abstract":"<jats:p>Alpha-melanocyte-stimulating hormone (<jats:italic>\u03b1<\/jats:italic>-MSH) is processed from proopiomelanocortin (POMC) and acts on the melanocortin receptors, MC3 and MC4. <jats:italic>\u03b1<\/jats:italic>-MSH plays a key role in energy homeostasis. In the present study, to shed light on the mechanisms by which <jats:italic>\u03b1<\/jats:italic>-MSH exerts its anorectic effects, extracellular neuronal activity was recorded in the hypothalamus and the dorsal vagal complex (DVC) of anesthetized rats. We examined the impact of <jats:italic>\u03b1<\/jats:italic>-MSH on glucose-sensing neurons and gastric distension (GD) sensitive neurons. In the lateral hypothalamus (LHA), <jats:italic>\u03b1<\/jats:italic>-MSH inhibited 75.0% of the glucose-inhibited (GI) neurons. In the ventromedial nucleus (VMN), most glucose-sensitive neurons were glucose-excited (GE) neurons, which were mainly activated by <jats:italic>\u03b1<\/jats:italic>-MSH. In the paraventricular nucleus (PVN), <jats:italic>\u03b1<\/jats:italic>-MSH suppressed the majority of GI neurons and excited most GE neurons. In the DVC, among the 20 GI neurons examined for a response to <jats:italic>\u03b1<\/jats:italic>-MSH, 1 was activated, 16 were depressed, and 3 failed to respond. Nineteen of 24 GE neurons were activated by <jats:italic>\u03b1<\/jats:italic>-MSH administration. Additionally, among the 42 DVC neurons examined for responses to GD, 23 were excited (GD-EXC) and 19 were inhibited (GD-INH). Fifteen of 20 GD-EXC neurons were excited, whereas 11 out of 14 GD-INH neurons were suppressed by <jats:italic>\u03b1<\/jats:italic>-MSH. All these responses were abolished by pretreatment with the MC3\/4R antagonist, SHU9119. In conclusion, the activity of glucose-sensitive neurons and GD-sensitive neurons in the hypothalamus and DVC can be modulated by <jats:italic>\u03b1<\/jats:italic>-MSH.<\/jats:p>","DOI":"10.1155\/2017\/2034691","type":"journal-article","created":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T18:30:50Z","timestamp":1511721050000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["<i>\u03b1<\/i>-MSH Influences the Excitability of Feeding-Related Neurons in the Hypothalamus and Dorsal Vagal Complex of Rats"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3014-0007","authenticated-orcid":true,"given":"Hong-Zai","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Clinical Hematology, Medical College, Qingdao University, Qingdao, 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