{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:29:58Z","timestamp":1771950598836,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Agaricus blazei<\/jats:italic>Murill is an edible mushroom of the Basidiomycetes family, which has been found to contain a number of compounds with antitumor properties, such as proteoglycans and ergosterol. In the present investigation, we show that the commercial mushroom product Andosan, which contains 82.4%<jats:italic>Agaricus blazei<\/jats:italic>Murill, together with medicinal mushrooms<jats:italic>Hericium erinaceus<\/jats:italic>(14.7%) and<jats:italic>Grifola frondosa<\/jats:italic>(2.9%), has a cytotoxic effect on primary myeloma cells, other myeloma cell lines, and leukemia cell lines<jats:italic>in vitro.<\/jats:italic>Although the exact content and hence the mechanisms of action of the Andosan extract are unknown, we have found in this investigation indications of cell cycle arrest when myeloma cell lines are cultivated with Andosan. This may be one of the possible explanations for the cytotoxic effects of Andosan.<\/jats:p>","DOI":"10.1155\/2017\/2059825","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T18:30:36Z","timestamp":1510079436000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the<i>Agaricus blazei<\/i>Murill Based Mushroom Extract, Andosan\u2122"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-7746","authenticated-orcid":true,"given":"Jon-Magnus","family":"Tangen","sequence":"first","affiliation":[{"name":"Department of Acute Medicine, Oslo University Hospital, Ullev\u00e5l, Kirkeveien 166, 0407 Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, P.O. Box 1171, 0318 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toril","family":"Holien","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), St. Olav\u2019s University Hospital, Prinsesse Kristinas Gate 1, 7006 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Mirlashari","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine, Oslo University Hospital, Ullev\u00e5l, Kirkeveien 166, 0407 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Misund","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), St. Olav\u2019s University Hospital, Prinsesse Kristinas Gate 1, 7006 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-3436","authenticated-orcid":true,"given":"Geir","family":"Hetland","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, P.O. 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