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Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50\u2009mg\/kg\/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition.<\/jats:p>","DOI":"10.1155\/2017\/2172981","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T23:31:04Z","timestamp":1513726264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Chrysin Administration Protects against Oxidative Damage in Varicocele\u2010Induced Adult Rats"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8686-144X","authenticated-orcid":false,"given":"Gabriela","family":"Missassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-811X","authenticated-orcid":false,"given":"Cibele","family":"dos Santos Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-3825","authenticated-orcid":false,"given":"Josiane","family":"de Lima Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-2413","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Villela e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Airton","family":"da Cunha Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2498-0619","authenticated-orcid":false,"suffix":"Jr.","given":"Fernando","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-5123","authenticated-orcid":false,"given":"Wilma","family":"De Grava Kempinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei429"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55089-4"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.08.010"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(93)90268-F"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.109.008698"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.5.461"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.170441"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2605.2001.00296.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.01.060"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.05.029"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62531-X"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2013.08.001"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2011.08.009"},{"key":"e_1_2_8_14_2","first-page":"459","article-title":"The role of flaxseed and vitamin E on oxidative stress in prepubertal rats with experimental varicocele: an experimental study","volume":"11","author":"Sohrabipour S.","year":"2013","journal-title":"Iranian Journal of Reproductive Medicine"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-16-0025"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6474163"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh257"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2015.01.008"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.05.018"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2015.03.019"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-34400"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.04.010"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/109662002753723214"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2010.01127.x"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0282"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1830-4"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/602360"},{"key":"e_1_2_8_28_2","volume-title":"Histological and Histopathological Evaluation of the Testis","author":"Russell L. 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