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In the present study, the effect of IFN-<jats:italic>\u03c4<\/jats:italic>on<jats:italic>S. aureus<\/jats:italic>growth was monitored by turbidimeter at 600 nm. IFN-<jats:italic>\u03c4<\/jats:italic>did not affect<jats:italic>S. aureus<\/jats:italic>growth. The histopathological changes indicated that IFN-<jats:italic>\u03c4<\/jats:italic>had a protective effect on uterus tissues with<jats:italic>S. aureus<\/jats:italic>infection. The ELISA and qPCR results showed the production of the proinflammatory cytokines TNF-<jats:italic>\u03b1<\/jats:italic>, IL-1<jats:italic>\u03b2<\/jats:italic>, and IL-6 was decreased with IFN-<jats:italic>\u03c4<\/jats:italic>treatment. In contrast, the level of the anti-inflammatory cytokine IL-10 was increased. We further studied the signaling pathway associated with these observations, and the qPCR results showed that the expression of TLR2 was repressed by IFN-<jats:italic>\u03c4<\/jats:italic>. Furthermore, the western blotting results showed the phosphorylation of I<jats:italic>\u03ba<\/jats:italic>B, NF-<jats:italic>\u03ba<\/jats:italic>B p65, and MAPKs (p38, JNK, and ERK) was inhibited by IFN-<jats:italic>\u03c4<\/jats:italic>treatment. The results suggested that IFN-<jats:italic>\u03c4<\/jats:italic>may be a potential drug for the treatment of uterine infection due to<jats:italic>S. aureus<\/jats:italic>or other infectious inflammatory diseases.<\/jats:p>","DOI":"10.1155\/2017\/2350482","type":"journal-article","created":{"date-parts":[[2017,2,26]],"date-time":"2017-02-26T21:00:29Z","timestamp":1488142829000},"page":"1-12","source":"Crossref","is-referenced-by-count":7,"title":["IFN-<i>\u03c4<\/i>Displays Anti-Inflammatory Effects on<i>Staphylococcus aureus<\/i>Endometritis via Inhibiting the Activation of the NF-<i>\u03ba<\/i>B and MAPK Pathways in Mice"],"prefix":"10.1155","volume":"2017","author":[{"given":"Zhenbiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, 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