{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:05:48Z","timestamp":1793397948261,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006302","name":"University of Alcal\u00e1","doi-asserted-by":"crossref","award":["PI14\/01935"],"award-info":[{"award-number":["PI14\/01935"]}],"id":[{"id":"10.13039\/501100006302","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/01935"],"award-info":[{"award-number":["PI14\/01935"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . The aim of this study was to summarize evidence on the effectiveness of therapeutic exercise in Fibromyalgia Syndrome.\n                    <jats:italic>Design<\/jats:italic>\n                    . Studies retrieved from the Cochrane Plus, PEDro, and Pubmed databases were systematically reviewed. Randomized controlled trials and meta-analyses involving adults with fibromyalgia were included. The primary outcomes considered in this systematic review were pain, global well-being, symptoms of depression, and health-related quality of life.\n                    <jats:italic>Results<\/jats:italic>\n                    . Effects were summarized using standardized mean differences with 95% confidence intervals using a random effects model. This study provides strong evidence that physical exercise reduces pain (\u22121.11 [95% CI] \u22121.52; \u22120.71; overall effect\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ), global well-being (\u22120.67 [95% CI] \u22120.89, \u22120.45;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ), and symptoms of depression (\u22120.40 [95% CI] \u22120.55, \u22120.24;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ) and that it improves both components of health-related quality of life (physical: 0.77 [95% CI] 0.47; 1.08;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ; mental: 0.49 [95% CI] 0.27; 0.71;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . This study concludes that aerobic and muscle strengthening exercises are the most effective way of reducing pain and improving global well-being in people with fibromyalgia and that stretching and aerobic exercises increase health-related quality of life. In addition, combined exercise produces the biggest beneficial effect on symptoms of depression.\n                  <\/jats:p>","DOI":"10.1155\/2017\/2356346","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T17:00:59Z","timestamp":1505926859000},"page":"1-14","source":"Crossref","is-referenced-by-count":169,"title":["Effectiveness of Therapeutic Exercise in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9000-8326","authenticated-orcid":true,"given":"M. Dolores","family":"Sosa-Reina","sequence":"first","affiliation":[{"name":"Department of Medicine and Medical Specialty, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, Alcal\u00e1 de Henares, Spain"},{"name":"Immune System Diseases-Rheumatology and Oncology Service, University Hospital \u201cPr\u00edncipe de Asturias\u201d, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9206-6725","authenticated-orcid":true,"given":"Susana","family":"Nunez-Nagy","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-8434","authenticated-orcid":true,"given":"Tom\u00e1s","family":"Gallego-Izquierdo","sequence":"additional","affiliation":[{"name":"Department of Nursing 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