{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:43:38Z","timestamp":1760550218305,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. There are several diagnostic methods for<jats:italic>Helicobacter pylori (H. pylori)<\/jats:italic>infection. A cost-effective analysis is needed to decide on the optimal diagnostic method. The aim of this study was to determine a cost-effective diagnostic method in patients with atrophic gastritis (AG).<jats:italic>Methods<\/jats:italic>. A decision-analysis model including seven diagnostic methods was constructed for patients with AG diagnosed by esophagogastroduodenoscopy. Expected values of cost and effectiveness were calculated for each test.<jats:italic>Results<\/jats:italic>. If the prevalence of<jats:italic>H. pylori<\/jats:italic>in the patients with AG is 85% and CAM-resistant<jats:italic>H. pylori<\/jats:italic>is 30%, histology, stool<jats:italic>H. pylori<\/jats:italic>antigen (SHPAg), bacterial culture (BC), and urine<jats:italic>H. pylori<\/jats:italic>antibody (UHPAb) were dominated by serum<jats:italic>H. pylori<\/jats:italic>IgG antibody (SHPAb), rapid urease test (RUT), and urea breath test (UBT). Among three undominated methods, the incremental cost-effective ratios (ICER) of RUT versus SHPAb and UBT versus RUT were $214 and $1914, respectively. If the prevalence of CAM-sensitive<jats:italic>H. pylori<\/jats:italic>was less than 55%, BC was not dominated, but its<jats:italic>H. pylori<\/jats:italic>eradication success rate was 0.86.<jats:italic>Conclusions<\/jats:italic>. RUT was the most cost-effective at the current prevalence of CAM-resistant<jats:italic>H. pylori<\/jats:italic>. BC could not be selected due to its poor effectiveness even if CAM-resistant<jats:italic>H. pylori<\/jats:italic>was more than 45%.<\/jats:p>","DOI":"10.1155\/2017\/2453254","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T16:54:24Z","timestamp":1487868864000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Cost-Effectiveness Analysis of<i>Helicobacter pylori<\/i>Diagnostic Methods in Patients with Atrophic Gastritis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-239X","authenticated-orcid":true,"given":"Fumio","family":"Omata","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, St. Luke\u2019s International Hospital, Chuo-Ku, Japan"},{"name":"Center for Clinical Epidemiology, St. Luke\u2019s International University, Chuo-Ku, 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