{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:05:24Z","timestamp":1773752724189,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"11th Five-Year National Science and Technology Major Project","award":["2009ZX10001-018"],"award-info":[{"award-number":["2009ZX10001-018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"Background\/Aims<\/jats:italic>. Many patients had to transfer to tenofovir disoproxil fumarate (TDF) if there is other nucleos(t)ide analogue (NA) resistance. We aimed to investigate antiviral effects of TDF monotherapy between NA-naive and NA-experienced chronic hepatitis B (CHB) patients in China. Methods<\/jats:italic>. A total of 102 NA-naive and NA-experienced CHB patients with TDF monotherapy (300\u2009mg\/day) were retrospectively analyzed for useful parameters up to 72 weeks. Results<\/jats:italic>. There were 36 and 66 patients with matched HBV DNA baseline level in NA-na\u00efve and NA-experienced group, respectively. There were no significant differences between NA-na\u00efve and NA-experienced groups in HBV DNA levels (all P<\/mml:mi>><\/mml:mo>0.05<\/mml:mn><\/mml:math>) and HBV DNA undetectable rates (all P<\/mml:mi>><\/mml:mo>0.05<\/mml:mn><\/mml:math>) at all time points. At the end of follow-up, HBV DNA undetectable rates in NA-na\u00efve and NA-experienced group were 96.2% (25\/26) and 91.8% (45\/49), respectively (P<\/mml:mi>=<\/mml:mo>0.476<\/mml:mn><\/mml:math>). Baseline HBV DNA level was the only independent predictor for HBV DNA negative time (P<\/mml:mi>=<\/mml:mo>0.018<\/mml:mn><\/mml:math>). In addition, 27.8% (5\/18) and 11.4% (4\/35) achieved HBeAg seroconversion at the end of the follow-up, respectively (P<\/mml:mi>=<\/mml:mo>0.133<\/mml:mn><\/mml:math>). Conclusions<\/jats:italic>. TDF monotherapy was effective regardless of prior NA experienced. Baseline HBV DNA was a key predictive factor for HBV DNA negative time in TDF monotherapy.<\/jats:p>","DOI":"10.1155\/2017\/2463197","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T09:10:30Z","timestamp":1491988230000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["TDF Monotherapy Is Effective Regardless of Prior Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patients in China"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7884-8752","authenticated-orcid":true,"given":"Mingxing","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, The Fifth Affiliated Hospital of Sun Yat-sen University (SYSU), Zhuhai, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoli","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University (SYSU), Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University (SYSU), Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuankai","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University (SYSU), Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusheng","family":"Jie","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University (SYSU), Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Lerner Research Institute, Cleveland, OH 44195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5184-4604","authenticated-orcid":true,"given":"Yutian","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University (SYSU), Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"9963","key":"1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","volume":"385","year":"2015","journal-title":"The 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