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PPAR-<jats:italic>\u03b3<\/jats:italic> is highly expressed in human sebaceous glands. Disruption of PPAR-<jats:italic>\u03b3<\/jats:italic> is believed to be one of the mechanisms of primary cicatricial alopecia (PCA) pathogenesis, causing pilosebaceous dysfunction leading to follicular inflammation. In this review article, we discuss the pathogenesis of PCA with a focus on PPAR-<jats:italic>\u03b3<\/jats:italic> involvement in pathogenesis of lichen planopilaris (LPP), the most common lymphocytic form of PCA. 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