{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:46:06Z","timestamp":1778809566828,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Clinical evidences have highlighted the efficacy of myo-inositol and selenium in the treatment of autoimmune thyroiditis. Aim of this study was to further analyze the role of myo-inositol plus selenium (Myo-Ins-Se) in restoring a normal thyroid function of Hashimoto\u2019s patients with subclinical hypothyroidism. Eighty-six patients with Hashimoto\u2019s thyroiditis having thyroid-stimulating hormone (TSH) levels between 3 and 6\u2009mIU\/L, elevated serum antithyroid peroxidase (TPOAb) and\/or antithyroglobulin (TgAb), and normal free thyroxine (fT<jats:sub>4<\/jats:sub>) and free triiodothyronine (fT<jats:sub>3<\/jats:sub>) levels were enrolled in the study: one hyperthyroid subject with TSH about 0.14\u2009<jats:italic>\u03bc<\/jats:italic>U\/ml was included in this trial as a single case. Patients were assigned to receive Myo-Ins-Se. TSH, TPOAb, and TgAb levels were significantly decreased in patients treated with combined Myo-Ins-Se after 6 months of treatment. In addition, a significant fT<jats:sub>3<\/jats:sub>and fT<jats:sub>4<\/jats:sub>increase, along with an amelioration of their quality of life, was observed. Remarkably, TSH values of the hyperthyroid patient increased from 0.14\u2009<jats:italic>\u03bc<\/jats:italic>U\/ml up to 1.02\u2009<jats:italic>\u03bc<\/jats:italic>U\/ml, showing a complete restoration of TSH values at a normal range. In conclusion, the administration of Myo-Ins-Se is significantly effective in decreasing TSH, TPOAb, and TgAb levels, as well as enhancing thyroid hormones and personal wellbeing, therefore restoring euthyroidism in patients diagnosed with autoimmune thyroiditis.<\/jats:p>","DOI":"10.1155\/2017\/2549491","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T07:03:26Z","timestamp":1487228606000},"page":"1-6","source":"Crossref","is-referenced-by-count":43,"title":["Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Patients with Autoimmune Thyroiditis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6820-2512","authenticated-orcid":true,"given":"Maurizio","family":"Nordio","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, University \u201cSapienza\u201d, Rome, 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