{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:57:04Z","timestamp":1760623024649,"version":"3.41.2"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":130,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, ICT, and Future Planning","award":["2009-0063466"],"award-info":[{"award-number":["2009-0063466"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Menopause is associated with a decrease in the level of sex hormones such as ovarian estradiol and progesterone and can cause various symptoms such as depression, hot flash, fatigue, heart palpitations, and headache. Furthermore, there is a risk of developing complications such as osteoporosis, cardiovascular diseases, Alzheimer\u2019s disease, and ovarian cancer. Schisandrae Fructus (SF) is widely used in Korean medicine as a cure for such complications. This study was conducted to evaluate the therapeutic effects of SF against menopause symptoms associated with follicle depletion caused by the industrial chemical 4\u2010vinylcyclohexene diepoxide (VCD) in mice. VCD directly targets the preantral follicles. Mice were injected with VCD (160\u2009mg\/kg intraperitoneally) daily for 15 days and then with SF dosage 3 times\/week for six weeks. To evaluate the effects of SF, body weight, tail skin temperature, uterine weight, lipid profile, and osteocalcin levels were measured. A decrease in body weight and tail skin temperature and an increase in uterine weight were observed upon SF treatment. Moreover, SF treatment significantly decreased total cholesterol, triglyceride, osteocalcin, and low\u2010density lipoprotein levels and low\u2010density\/high\u2010density lipoprotein ratio. These results suggest the potential use of SF in the treatment of menopausal symptoms in women.<\/jats:p>","DOI":"10.1155\/2017\/2564787","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T21:03:59Z","timestamp":1494536639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Schisandrae Fructus Reduces Symptoms of 4\u2010Vinylcyclohexene Diepoxide\u2010Induced Ovarian Failure in Mice"],"prefix":"10.1155","volume":"2017","author":[{"given":"Dasom","family":"Shin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhee","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Bin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geun-Hyung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9179-0797","authenticated-orcid":false,"given":"Deok-Sang","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-3582","authenticated-orcid":false,"given":"Hyunsu","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.01.015"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4fo00133h"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.07.053"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2010.03.028"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1347.020"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00036"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.4.485"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.397"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.19.1.55"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.12.064"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080309"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-6009(91)90108-C"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000191883.59799.2e"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/019262301301418892"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(02)00048-5"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(02)99502-5"},{"key":"e_1_2_8_17_2","article-title":"The 4-vinylcyclohexene diepoxide (VCD)-treated rat provides a unique preclinical model to study peri- menopausal hot flushes","volume":"2","author":"Merchenthaler I.","year":"2014","journal-title":"Journal of Endocrinology, Diabetes & Obesity"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.01.019"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/472638"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu6125667"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028335"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.04.020"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2012.10.003"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01815430"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-010-0187-y"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90762.2008"},{"key":"e_1_2_8_27_2","first-page":"980","article-title":"Alternative supplement for enhancement of reproductive health and metabolic profile among perimenopausal women: a novel role of Nigella sativa","volume":"17","author":"Latiff L. A.","year":"2014","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_8_28_2","first-page":"613","article-title":"Reproductive ageing and the menopause","volume":"45","author":"Finn C. A.","year":"2001","journal-title":"The International Journal of Developmental Biology"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004925"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.7.605"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-1-199501010-00002"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2011.648820"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00057.2014"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000010058"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1802"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg077"},{"key":"e_1_2_8_37_2","first-page":"443","article-title":"Effects of impending ovarian failure induced by 4-vinylcyclohexene diepoxide on fertility in C57BL\/6 female mice","volume":"57","author":"Haas J. R.","year":"2007","journal-title":"Comparative Medicine"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.08.003"},{"key":"e_1_2_8_39_2","first-page":"523","article-title":"Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause","volume":"55","author":"Lohff J. C.","year":"2005","journal-title":"Comparative Medicine"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117414"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14065-2"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.24.3243"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10233-7"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa030808"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1550-8579(05)80061-0"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2006.01.004"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2013.09.009"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.10.016"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0367-326x(99)00102-1"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1039\/c6fo00328a"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079418"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/np0503707"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119214"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b15-01020"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-958032"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2011.571682"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.03.037"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.54"},{"key":"e_1_2_8_59_2","first-page":"13","article-title":"Lack of estrogen down-regulates CXCR4 expression on Treg cells and reduces Treg cell population in bone marrow in OVX mice","volume":"61","author":"Fan X. L.","year":"2015","journal-title":"Cellular and Molecular Biology"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2013.07.003"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.120840"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.166"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.10.1675"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30489-8"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.07.010"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181f8565e"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.23.3.279"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2017\/2564787.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2017\/2564787.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/2564787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:38:58Z","timestamp":1722908338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/2564787"}},"subtitle":[],"editor":[{"given":"Jairo Kennup","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/2564787"],"URL":"https:\/\/doi.org\/10.1155\/2017\/2564787","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2564787"}}