{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:25:10Z","timestamp":1793024710068,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["LRGS 1\/2012"],"award-info":[{"award-number":["LRGS 1\/2012"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003967","name":"Iran\u2019s National Elites Foundation","doi-asserted-by":"publisher","award":["LRGS 1\/2012"],"award-info":[{"award-number":["LRGS 1\/2012"]}],"id":[{"id":"10.13039\/501100003967","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>To investigate the prebiotic and immunomodulatory effects of PKC extract (OligoPKC) a total of 24 male rats were randomly assigned to three treatment groups receiving basal diet (control), basal diet containing 0.5% OligoPKC, or basal diet containing 1% OligoPKC for four weeks. We found that OligoPKC had no significant effect on the tested growth parameters. However, it increased the size of the total and beneficial bacterial populations while reducing pathogen populations. OligoPKC increased the concentration of immunoglobulins in the serum and cecal contents of rats. It also enhanced the antioxidant capacity of the liver while reducing lipid peroxidation in liver tissue. OligoPKC affected the expression of genes involved in immune system function in the intestine. Therefore, OligoPKC could be considered a potential mannan-based prebiotic for humans and animals due to its beneficial effects on the health and well-being of the model rats.<\/jats:p>","DOI":"10.1155\/2017\/2576921","type":"journal-article","created":{"date-parts":[[2017,11,19]],"date-time":"2017-11-19T23:30:39Z","timestamp":1511134239000},"page":"1-10","source":"Crossref","is-referenced-by-count":9,"title":["Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-5522","authenticated-orcid":true,"given":"Mohammd","family":"Faseleh Jahromi","sequence":"first","affiliation":[{"name":"Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM), 43400 Serdang, Malaysia"},{"name":"Agriculture Biotechnology Research Institute of Iran (ABRII), East and North-East Branch, P.O. Box 91735 844, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-2810","authenticated-orcid":true,"given":"Parisa","family":"Shokryazdan","sequence":"additional","affiliation":[{"name":"Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM), 43400 Serdang, Malaysia"},{"name":"Agriculture Biotechnology Research Institute of Iran (ABRII), East and North-East Branch, P.O. Box 91735 844, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulkifli","family":"Idrus","sequence":"additional","affiliation":[{"name":"Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM), 43400 Serdang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohollah","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM), 43400 Serdang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Bashokouh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6024-0856","authenticated-orcid":true,"given":"Juan Boo","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM), 43400 Serdang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"6","key":"1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/jn\/125.6.1401","volume":"125","year":"1995","journal-title":"Journal of Nutrition"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510003363"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-6946(99)00044-8"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2008.09.001"},{"key":"5","year":"2013"},{"issue":"1","key":"6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/jn\/134.1.153","volume":"134","year":"2004","journal-title":"Journal of Nutrition"},{"key":"7","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1093\/jn\/137.11.2563S","volume":"137","year":"2007","journal-title":"Journal of Nutrition"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i3.225"},{"key":"10","first-page":"11","volume":"75","year":"2003","journal-title":"Feedstuffs"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/86.6.1070"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1080\/00071660802290408"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1080\/00071660801998613"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3923\/jas.2014.1473.1476"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4081\/ijas.2015.3452"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1017\/jan.2015.6"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184553"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-015-1103-x"},{"key":"20","year":"1996"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/149745"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.5897\/AJPP11.059"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"issue":"10","key":"24","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0022-2275(20)35737-0","volume":"34","year":"1993","journal-title":"Journal of Lipid Research"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0309-1740(97)00113-7"},{"key":"27","year":"2006"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.15376\/biores.11.1.674-695"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1021\/jf200859z"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041256"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2005.117"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-1311-0_5"},{"issue":"3","key":"33","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/ibd.20737","volume":"15","year":"2009","journal-title":"Inflammatory Bowel Diseases"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2937"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0681357"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01515-08"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1080\/17450390500216928"},{"key":"39","first-page":"1","year":"2016","journal-title":"Medical Microbiology and Immunology"},{"key":"40","first-page":"135","volume-title":"Mechanisms of prebiotic impact on health","year":"2009"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26242"},{"issue":"12","key":"42","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.4049\/jimmunol.138.12.4303","volume":"138","year":"1987","journal-title":"The Journal of Immunology"},{"issue":"3","key":"43","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1128\/IAI.45.3.550-557.1984","volume":"45","year":"1984","journal-title":"Infection and Immunity"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2010.05.005"},{"issue":"5","key":"45","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1093\/jn\/137.5.1222","volume":"137","year":"2007","journal-title":"Journal of Nutrition"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i27.4352"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-010-9259-0"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(01)00183-0"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwf060"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2010.523416"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1021\/jf030172q"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-368"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.165886"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/2576921.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/2576921.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/2576921.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T18:32:07Z","timestamp":1693247527000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/2576921\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":49,"alternative-id":["2576921","2576921"],"URL":"https:\/\/doi.org\/10.1155\/2017\/2576921","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}