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Physical exercise can improve PS. However, the effect of exercise on the CGP, and whether this pathway is involved in the improvement of PS, remains unclear. Parkinson\u2019s disease (PD) was induced in rats by 6-hydroxydopamine injection into the right medial forebrain bundle. Motor function was assessed using the cylinder test. Striatal neuron (SN) spontaneous and evoked firing activity was recorded, and the expression levels of Cav1.3 and CaMKII in the striatum were measured after 4 weeks of treadmill exercise. The motor function in PD rats was improved by treadmill exercise. SN showed significantly enhanced excitability, and treadmill exercise reduced SN excitability in PD rats. In addition, firing activity was evoked in SNs by stimulation of the primary motor cortex, and SNs exhibited significantly decreased stimulus threshold, increased firing rates, and reduced latency. The expression of Cav1.3 and p-CaMKII (Thr286) in the striatum were enhanced in PD rats. However, these effects were reversed by treadmill exercise. These findings suggest that treadmill exercise inhibits CGP hyperactivity in PD rats, which may be related to improvement of PS.<\/jats:p>","DOI":"10.1155\/2017\/2583910","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T19:30:37Z","timestamp":1508873437000},"page":"1-11","source":"Crossref","is-referenced-by-count":24,"title":["Treadmill Exercise Improves Motor Dysfunction and Hyperactivity of the Corticostriatal Glutamatergic Pathway in Rats with 6-OHDA-Induced Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2017","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[{"name":"College of Physical Education and Sports, Beijing Normal University, Beijing 100875, China"},{"name":"Physical Education College, Hebei Normal University, Shijiazhuang, Hebei 050024, 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