{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:43:07Z","timestamp":1789411387050,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP52155"],"award-info":[{"award-number":["OPP52155"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass deworming chemotherapy. The reliance on a single drug, praziquantel, is a motivation for the search of novel antischistosomal compounds. This study investigated the anthelmintic activity of the stem bark and roots of<jats:italic>Rauwolfia vomitoria<\/jats:italic>against two life stages of<jats:italic>Schistosoma mansoni<\/jats:italic>. Both plant parts were found to be active against cercariae and adult worms. Within 2\u2009h of exposure all cercariae were killed at a concentration range of 62.5\u20131000\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL and 250\u20131000\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL of<jats:italic>R. vomitoria<\/jats:italic>stem bark and roots, respectively. The LC<jats:sub>50<\/jats:sub>values determined for the stem bark after 1 and 2\u2009h of exposure were 207.4 and 61.18\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL, respectively. All adult worms exposed to the concentrations range of 250\u20131000\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL for both plant parts died within 120\u2009h of incubation. The cytotoxic effects against HepG2 and Chang liver cell assessed using MTT assay method indicated that both plant extracts which were inhibitory to the proliferation of cell lines with IC<jats:sub>50<\/jats:sub>&gt; 20\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL appear to be safe. This report provides the first evidence of in vitro schistosomicidal potency of<jats:italic>R. vomitoria<\/jats:italic>with the stem bark being moderately, but relatively, more active and selective against schistosome parasites. This suggests the presence of promising medicinal constituent(s).<\/jats:p>","DOI":"10.1155\/2017\/2583969","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T19:28:50Z","timestamp":1488310130000},"page":"1-11","source":"Crossref","is-referenced-by-count":45,"title":["In Vitro Assessment of Anthelmintic Activities of<i>Rauwolfia vomitoria<\/i>(Apocynaceae) Stem Bark and Roots against Parasitic Stages of<i>Schistosoma mansoni<\/i>and Cytotoxic Study"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-0571","authenticated-orcid":true,"given":"Emmanuel Mouafo","family":"Tekwu","sequence":"first","affiliation":[{"name":"Laboratory for Tuberculosis Research and Pharmacology, Biotechnology Centre, Nkolbisson, University of Yaound\u00e9 1, Yaound\u00e9, Cameroon"},{"name":"Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences, University of Ghana, PO Box LG581 Legon, Accra, 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