{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:40:58Z","timestamp":1784641258436,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. The purpose of this study was to investigate the long-term clinical course of NTG patients who initiated intraocular pressure- (IOP-) lowering therapy.<jats:italic>Methods<\/jats:italic>. The present study included 72 normal-tension glaucoma (NTG) patients. The mean deviation (MD) was measured with visual fields. Nocturnal hypotension with weighted standard deviation (wSD) was determined by 24-hour ambulatory blood pressure monitoring. To identify risk factors for NTG progression, linear logistic regression analysis was employed.<jats:italic>Results<\/jats:italic>. The mean follow-up period was 21.2\u2009\u00b1\u20091.1 years. The mean MD progression rate was \u22120.28\u2009\u00b1\u20090.24\u2009dB\/year. The mean ocular perfusion pressure (OPP) was 52.1\u2009\u00b1\u20095.9\u2009mmHg. The mean wSD was 14.5\u2009\u00b1\u20092.2. In the univariate model, disc hemorrhage (RR 7.12;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>), IOP reduction rate (RR 2.12;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.045<\/mml:mn><\/mml:math>), and OPP (RR 1.94;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.027<\/mml:mn><\/mml:math>) were associated with glaucomatous visual field progression. However, in the multivariate model, the IOP reduction rate (RR 2.45;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.048<\/mml:mn><\/mml:math>) and OPP (RR 2.02;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>) were detected to be significant factors associated with progression.<jats:italic>Conclusions<\/jats:italic>. The mean rate of visual field progression was \u22120.28\u2009dB\/year in NTG patients treated with medical therapy. The IOP reduction rate and OPP were associated with glaucomatous visual field progression.<\/jats:p>","DOI":"10.1155\/2017\/2651645","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T22:13:24Z","timestamp":1491516804000},"page":"1-6","source":"Crossref","is-referenced-by-count":13,"title":["Long-Term Clinical Course of Normal-Tension Glaucoma: 20 Years of Experience"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-3303","authenticated-orcid":true,"given":"Sang Wook","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Dong-A University College of Medicine, Busan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yoon","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dong-A University College of Medicine, Busan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"5","key":"1","first-page":"774","volume":"36","year":"1995","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.03.029"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.10.016"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31782-8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31153-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)00964-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00223-2"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1268"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4867"},{"issue":"6","key":"10","first-page":"412","volume":"6","year":"1997","journal-title":"Journal of Glaucoma"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790601.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(05)80042-6"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000156134.38495.0b"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1053"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0615"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2767-3"},{"key":"18","year":"1980"},{"issue":"4","key":"19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/aos.12298","volume":"92","year":"2014","journal-title":"Acta Ophthalmologica"},{"issue":"8","key":"20","first-page":"S42","volume":"9","year":"1991","journal-title":"Journal of Hypertension. Supplement"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2003.00105.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0866"},{"issue":"3","key":"23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000310234","volume":"203","year":"1991","journal-title":"Ophthalmologica"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181f3eb81"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000243472.51461.24"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1159\/000309344"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1973.01000040459003"},{"issue":"3","key":"28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/aos.12277","volume":"92","year":"2014","journal-title":"Acta Ophthalmologica"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3716"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/2651645.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/2651645.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/2651645.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T10:22:27Z","timestamp":1498386147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2017\/2651645\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":29,"alternative-id":["2651645","2651645"],"URL":"https:\/\/doi.org\/10.1155\/2017\/2651645","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}