{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:34:49Z","timestamp":1785288889489,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T00:00:00Z","timestamp":1508284800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Molecular Imaging"],"published-print":{"date-parts":[[2017,10,18]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. This retrospective study evaluated whether the use of additional anterior <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><mml:mi mathvariant=\"normal\">c<\/mml:mi><\/mml:mrow><mml:mprescripts\/><mml:none\/><mml:mrow><mml:mn mathvariant=\"normal\">99<\/mml:mn><mml:mi mathvariant=\"normal\">m<\/mml:mi><\/mml:mrow><\/mml:mmultiscripts><\/mml:mrow><\/mml:math>-sestamibi\/<jats:sup>123<\/jats:sup>I pinhole imaging improves the outcome of <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><mml:mi mathvariant=\"normal\">c<\/mml:mi><\/mml:mrow><mml:mprescripts\/><mml:none\/><mml:mrow><mml:mn mathvariant=\"normal\">99<\/mml:mn><mml:mi mathvariant=\"normal\">m<\/mml:mi><\/mml:mrow><\/mml:mmultiscripts><\/mml:mrow><\/mml:math>-sestamibi\/<jats:sup>123<\/jats:sup>I subtraction SPECT\/CT in parathyroid scintigraphy (PS).<jats:italic> Materials and Methods<\/jats:italic>. PS using simultaneous dual-isotope subtraction methods and an acquisition protocol combining SPECT\/CT and planar pinhole imaging was performed for 175 patients with primary or secondary hyperparathyroidism. All patients who proceeded to surgery with complete postsurgery laboratory findings were included in this study <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">94<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. SPECT\/CT images alone and combined with pinhole images were evaluated.<jats:italic> Results<\/jats:italic>. There were 111 enlarged parathyroid glands of which 104 and 108 glands were correctly visualized by SPECT\/CT (seven false positives) or SPECT\/CT with pinhole (three false positives), respectively. Both sensitivity and specificity were higher with combined SPECT\/CT with pinhole than with SPECT\/CT alone (97% versus 94% and 99% versus 98%, resp., not significant). The false-positive rate was 6% with SPECT\/CT and decreased to 3% using combined SPECT\/CT with pinhole.<jats:italic> Conclusion<\/jats:italic>. <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><mml:mi mathvariant=\"normal\">c<\/mml:mi><\/mml:mrow><mml:mprescripts\/><mml:none\/><mml:mrow><mml:mn mathvariant=\"normal\">99<\/mml:mn><mml:mi mathvariant=\"normal\">m<\/mml:mi><\/mml:mrow><\/mml:mmultiscripts><\/mml:mrow><\/mml:math>-sestamibi\/<jats:sup>123<\/jats:sup>I subtraction SPECT\/CT is a highly sensitive and specific protocol for PS. The use of additional anterior pinhole imaging increases both sensitivity and specificity of PS, although this increase is not statistically significant.<\/jats:p>","DOI":"10.1155\/2017\/2712018","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T23:31:19Z","timestamp":1508369479000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["<sup>99m<\/sup>Tc-Sestamibi\/<sup>123<\/sup>I Subtraction SPECT\/CT in Parathyroid Scintigraphy: Is Additional Pinhole Imaging Useful?"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2683-1000","authenticated-orcid":true,"given":"Virpi","family":"Tunninen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Satakunta Central Hospital, Sairaalantie 3, 28500 Pori, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Varjo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Satakunta Central Hospital, Sairaalantie 3, 28500 Pori, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi","family":"Kauppinen","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital, HUS Medical Imaging Center, P.O. Box 340, 00029 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4282-6479","authenticated-orcid":true,"given":"Anu","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Satakunta Central Hospital, Sairaalantie 3, 28500 Pori, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Eskola","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Sciences, Tampere University of Technology, P.O. Box 692, 33101 Tampere, Finland"},{"name":"Regional Imaging Center, Tampere University Hospital, P.O. Box 2000, 33521 Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Sepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Turku PET Centre, Turku University Hospital, P.O. Box 52, 20521 Turku, Finland"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, P.O. 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