{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:05:04Z","timestamp":1789423504052,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic> Neonates have a high risk of oxidative stress during anesthetic procedures. The predictive role of oxidative stress biomarkers on the occurrence of brain injury in the perioperative period has not been reported before. <jats:italic>Methods.<\/jats:italic> A prospective cohort study of patients requiring major surgery in the neonatal period was conducted. Biomarker levels of nonprotein-bound iron (NPBI) in plasma and F<jats:sub>2<\/jats:sub>-isoprostane in plasma and urine before and after surgical intervention were determined. Brain injury was assessed using postoperative MRI. <jats:italic>Results.<\/jats:italic> In total, 61 neonates were included, median gestational age at 39 weeks (range 31\u201342) and weight at 3000 grams (1400\u20134400). Mild to moderate brain lesions were found in 66%. Logistic regression analysis showed a significant difference between plasma NPBI in patients with nonparenchymal injury versus no brain injury: 1.34\u2009umol\/L was identified as correlation threshold for nonparenchymal injury (sensitivity 67%, specificity 91%). In the multivariable analysis, correcting for GA, no other significant relation was found with the oxidative stress biomarkers and risk factors. <jats:italic>Conclusion.<\/jats:italic> Oxidative stress seems to occur during anaesthesia in this cohort of neonates. Plasma nonprotein-bound iron showed to be associated with nonparenchymal injury after surgery, with values of 1.34\u2009umol\/L or higher. Risk factors should be elucidated in a more homogeneous patient group.<\/jats:p>","DOI":"10.1155\/2017\/2728103","type":"journal-article","created":{"date-parts":[[2017,10,8]],"date-time":"2017-10-08T17:01:14Z","timestamp":1507482074000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Predictive Role of F<sub>2<\/sub>-Isoprostanes as Biomarkers for Brain Damage after Neonatal Surgery"],"prefix":"10.1155","volume":"2017","author":[{"given":"L. J.","family":"Stolwijk","sequence":"first","affiliation":[{"name":"Department of Neonatology, University Medical Center Utrecht, Utrecht, Netherlands"},{"name":"Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands"},{"name":"Department of Pediatric Surgery, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M. A.","family":"Lemmers","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Y. A.","family":"van Herwaarden","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. C.","family":"van der Zee","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"van Bel","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-1637","authenticated-orcid":true,"given":"F.","family":"Groenendaal","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Tataranno","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University Medical Center Utrecht, Utrecht, Netherlands"},{"name":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Calderisi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Longini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-4295","authenticated-orcid":true,"given":"F.","family":"Bazzini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-9168","authenticated-orcid":true,"given":"M. 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