{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:07:07Z","timestamp":1788455227339,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","award":["PHD55K0050"],"award-info":[{"award-number":["PHD55K0050"]}],"id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Royal Golden Jubilee Ph.D. Program","award":["PHD55K0050"],"award-info":[{"award-number":["PHD55K0050"]}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["PHD55K0050"],"award-info":[{"award-number":["PHD55K0050"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2017]]},"abstract":"Severe cutaneous adverse drug reactions (SCARs) are life-threatening reactions. The strong association between theHLA-B<\/jats:italic>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/jats:italic>allele and allopurinol-induced SCARs is well recognized. Screening forHLA-B<\/jats:italic>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/jats:italic>allele before prescribing allopurinol in some populations has been recommended. Several single-nucleotide polymorphisms (SNPs) in chromosome 6 have been found to be tightly linked with theHLA<\/jats:italic>allele, and these SNPs have been proposed as surrogate markers of theHLA-B<\/jats:italic>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/jats:italic>allele. This study aimed to evaluate the association between three SNPs in chromosome 6 and allopurinol-induced SCARs in a Thai population. The linkage disequilibrium between theHLA-B<\/jats:italic>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/jats:italic>allele and these SNPs was also evaluated. Results showed that three SNPs including rs9263726, rs2734583, and rs3099844 were significantly associated with allopurinol-induced SCARs but with a lower degree of association when compared with theHLA-B<\/jats:italic>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/jats:italic>allele. The sensitivity, specificity, PPV, and NPV of these SNPs were comparable to those of theHLA-B<\/jats:italic>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/jats:italic>allele. Although detection of the SNP is simpler and less expensive compared with that of theHLA-B<\/jats:italic>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/jats:italic>allele, these SNPs were not perfectly linked with theHLA-B<\/jats:italic>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/jats:italic>allele. Screening using these SNPs as surrogate markers of theHLA-B<\/jats:italic>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/jats:italic>allele to avoid SCARs prior to allopurinol administration needs caution because of their imperfect linkage with theHLA-B<\/jats:italic>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/jats:italic>allele.<\/jats:p>","DOI":"10.1155\/2017\/2738784","type":"journal-article","created":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T23:31:00Z","timestamp":1513553460000},"page":"1-9","source":"Crossref","is-referenced-by-count":18,"title":["Comparison between theHLA-B<\/i>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>58\u2009:\u200901<\/i>Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions"],"prefix":"10.1155","volume":"2017","author":[{"given":"Niwat","family":"Saksit","sequence":"first","affiliation":[{"name":"Department of 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