{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T17:48:46Z","timestamp":1776188926450,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["QTJ13009"],"award-info":[{"award-number":["QTJ13009"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["2007BAI18B08"],"award-info":[{"award-number":["2007BAI18B08"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["2009B44"],"award-info":[{"award-number":["2009B44"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"publisher","award":["QTJ13009"],"award-info":[{"award-number":["QTJ13009"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"publisher","award":["2007BAI18B08"],"award-info":[{"award-number":["2007BAI18B08"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"publisher","award":["2009B44"],"award-info":[{"award-number":["2009B44"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National 11th Five-year Plan Science and Technology Supporting Programs","award":["QTJ13009"],"award-info":[{"award-number":["QTJ13009"]}]},{"name":"National 11th Five-year Plan Science and Technology Supporting Programs","award":["2007BAI18B08"],"award-info":[{"award-number":["2007BAI18B08"]}]},{"name":"National 11th Five-year Plan Science and Technology Supporting Programs","award":["2009B44"],"award-info":[{"award-number":["2009B44"]}]},{"name":"Beijing Science & Technology Novel Star Program","award":["QTJ13009"],"award-info":[{"award-number":["QTJ13009"]}]},{"name":"Beijing Science & Technology Novel Star Program","award":["2007BAI18B08"],"award-info":[{"award-number":["2007BAI18B08"]}]},{"name":"Beijing Science & Technology Novel Star Program","award":["2009B44"],"award-info":[{"award-number":["2009B44"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To compare laser peripheral iridotomy (LPI) with trabeculectomy as an initial treatment for primary angle-closure glaucoma (PACG) with peripheral anterior synechiae (PAS)\u2009\u2265\u20096 clock hours. <jats:italic>Methods<\/jats:italic>. Patients were drawn from two randomized controlled trials. 38 eyes of 38 patients (PAS\u2009\u2265\u20096 clock hours) were treated with LPI (group 1) while 111 eyes of 111 PACG patients (PAS\u2009\u2265\u20096 clock hours) underwent primary trabeculectomy (group 2). All patients underwent a comprehensive ophthalmic examination at baseline and at postoperative visits and were followed up for a minimum of one year. <jats:italic>Results<\/jats:italic>. Group 2 had higher baseline IOP (45.7\u2009\u00b1\u200914.8\u2009mmHg versus 34.3\u2009\u00b1\u200914.3\u2009mmHg) than group 1 and more clock hours of PAS (10.4\u2009\u00b1\u20091.9 versus 9.0\u2009\u00b1\u20092.2). IOPs at all postoperative visits were significantly lower in group 2 than in group 1 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.000<\/mml:mn><\/mml:math>). Five eyes in group 1 required trabeculectomy. 17 of the 38 eyes in group 1 (44.7%) required IOP-lowering medications as compared to seven of the 111 eyes in group 2 (6.3%). Cataract progression was documented in 2 eyes (5.3%) in group 1 and 16 eyes (14.4%) in group 2. <jats:italic>Conclusions<\/jats:italic>. Primary trabeculectomy for PACG (PAS\u2009\u2265\u20096 clock hours) is more effective than LPI in lowering IOP.<\/jats:p>","DOI":"10.1155\/2017\/2761301","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T17:01:24Z","timestamp":1504285284000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8045-2506","authenticated-orcid":true,"given":"Yan Yun","family":"Chen","sequence":"first","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jie","family":"Fan","sequence":"additional","affiliation":[{"name":"Handan Eye Hospital, Handan, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9685-7356","authenticated-orcid":true,"given":"Yuan Bo","family":"Liang","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, China"},{"name":"School of Medicine, Dentistry and Biomedical Sciences Public Health, Health Services and Primary Care, Queen\u2019s University, Belfast, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-6363","authenticated-orcid":true,"given":"Shi Song","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai Lin","family":"Meng","sequence":"additional","affiliation":[{"name":"Anyang Eye Hospital, Anyang, Henan Province, 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