{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:07:36Z","timestamp":1790996856167,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"crossref","award":["2012\/07\/B\/ST6\/01537"],"award-info":[{"award-number":["2012\/07\/B\/ST6\/01537"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>The aim of the present study was to evaluate the concentration of serum thrombomodulin (sTM) in the AAA patients and to examine its correlation with various factors which may potentially participate in the endothelial injury.<jats:italic>Materials and Methods.<\/jats:italic>Forty-one patients with AAA were involved and divided into subgroups based on different criteria. Concentration of sTM was measured using enzyme-linked-immunosorbent assay (ELISA). The results were compared with those obtained in 30 healthy age- and sex-matched volunteers.<jats:italic>Results.<\/jats:italic>The higher concentration of sTM was observed in AAA patients compared with those in controls volunteers [2.37 (1.97\u20132.82)\u2009ng\/mL versus 3.93 (2.43\u20139.20)\u2009ng\/mL,<jats:italic>P<\/jats:italic>&lt; 0.001]. An elevated sTM associated significantly with increased triglycerides (TAG) [<jats:italic>P<\/jats:italic>= 0.022], cholesterol [<jats:italic>P<\/jats:italic>= 0.029], hsCRP [<jats:italic>P<\/jats:italic>= 0.031], and advanced glycation end products (AGEs) [<jats:italic>P<\/jats:italic>= 0.033].<jats:italic>Conclusions.<\/jats:italic>The elevation of serum sTM level suggests that endothelial damage occurs in AAA pathogenesis. The correlations observed indicate that lipids abnormalities, inflammation, and oxidative stress may be involved in this destructive process.<\/jats:p>","DOI":"10.1155\/2017\/2791082","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T21:52:26Z","timestamp":1491256346000},"page":"1-10","source":"Crossref","is-referenced-by-count":13,"title":["The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2296-3599","authenticated-orcid":true,"given":"Magdalena","family":"Budzy\u0144","sequence":"first","affiliation":[{"name":"Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2414-6771","authenticated-orcid":true,"given":"Bogna","family":"Gryszczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wac\u0142aw","family":"Majewski","sequence":"additional","affiliation":[{"name":"University Hospital of Lord\u2019s Transfiguration, General and Vascular Surgery Clinic, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Krasi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of General and Vascular Surgery, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7169-0331","authenticated-orcid":true,"given":"Magdalena Paulina","family":"Kasprzak","sequence":"additional","affiliation":[{"name":"Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6691-3863","authenticated-orcid":true,"given":"Dorota","family":"Formanowicz","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Laboratory Medicine, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5505-9187","authenticated-orcid":true,"given":"Krzysztof Wojciech","family":"Strzy\u017cewski","sequence":"additional","affiliation":[{"name":"Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Iskra","sequence":"additional","affiliation":[{"name":"Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s1078-5884(96)80002-5"},{"issue":"3","key":"2","first-page":"993","volume":"150","year":"1997","journal-title":"American Journal of Pathology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7661"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3171\/jns-07\/08\/0405"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001677"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150826094156"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg037"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.12.030"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.652859"},{"issue":"4","key":"10","first-page":"355","volume":"12","year":"1993","journal-title":"International Angiology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1177\/096120339800700227"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/s0953-6205(00)00066-2"},{"key":"13","volume":"8, article p106","year":"2004","journal-title":"Critical Care"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(98)09057-6"},{"key":"15","first-page":"103","volume":"45","year":"1997","journal-title":"Acta Medica et Biologica"},{"issue":"1","key":"16","first-page":"59","volume":"15","year":"1997","journal-title":"Clinical and Experimental Rheumatology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01107.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199809000-00004"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.107563"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000214999.12921.4f"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000257552.94483.14"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1177\/153857440503900601"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00714.x"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.206573"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01353.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.91.9.2488"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199901143400207"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3107879"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05143.x"},{"issue":"1","key":"30","first-page":"134","volume":"87","year":"1996","journal-title":"Immunology"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01108.x"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2002.01469.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(93)90116-6"},{"issue":"3","key":"34","first-page":"233","volume":"25","year":"1996","journal-title":"Vasa\u2014Journal of Vascular Diseases"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)00230-6"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.11.002"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2011.02.065"},{"issue":"3","key":"38","first-page":"245","volume":"15","year":"2011","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.890774"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/598980"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(97)80080-9"},{"issue":"4","key":"42","first-page":"287","volume":"162","year":"1996","journal-title":"European Journal of Surgery, Acta Chirurgica"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2013.34412"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(96)80278-4"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/482728"},{"key":"46","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1056\/NEJMoa0909305","volume":"362","year":"2010","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"47","first-page":"39","volume":"45","year":"2007","journal-title":"South African Journal of Surgery"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.11.2843"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1179\/1351000212Y.0000000012"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.121124"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.3.236"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/0967-2109(95)00140-9"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.01.002"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/27.6.949"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00985-0"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(03)00412-X"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13634"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.1.78"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117315"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.156.8.843"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.3.355"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000013778.72404.30"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.01.278"},{"issue":"5","key":"64","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.4049\/jimmunol.161.5.2524","volume":"161","year":"1998","journal-title":"Journal of Immunology"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.3390\/biom5010194"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1278352"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000160342.20342.00"},{"issue":"6","key":"68","first-page":"597","volume":"51","year":"2002","journal-title":"Physiological Research"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65659-3"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.12945\/j.aorta.2013.13-047"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2013.11.006"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000103862.26506.3d"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.621854"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/2791082.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/2791082.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/2791082.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:07:33Z","timestamp":1692749253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/2791082\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":73,"alternative-id":["2791082","2791082"],"URL":"https:\/\/doi.org\/10.1155\/2017\/2791082","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}