{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:55:20Z","timestamp":1783004120537,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate the effect of hydroxychloroquine (HCQ) in pregnant women with systemic lupus erythematosus (SLE). <jats:italic>Methods<\/jats:italic>. In SLE pregnancies of a single Dutch center (2000\u20132015), lupus activity and flares before and during pregnancy and postpartum were assessed using the SLE Disease Activity Index (SLEDAI)\/SLEPDAI (SLEDAI adjusted for pregnancy). The association between HCQ use and pregnancy outcomes (early spontaneous abortion, fetal death, and preterm and term live birth) was analyzed using generalized estimating equations (GEE) accounting for the occurrence of multiple pregnancies per patient. Analyses were adjusted for antiphospholipid antibody (aPL) status. <jats:italic>Results<\/jats:italic>. 110 pregnancies (63 mostly Caucasian patients) were included, of which, in 30, HCQ was used; overall occurrence of flares was low (non-HCQ group: 5 mild (6.4%) and 2 severe (2.6%); HCQ group: 2 mild (6.7%) and no severe flares). The HCQ group showed a trend towards lower dosage of prednisone (OR 0.2 (95% CI 0.0\u20131.4); <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.10<\/mml:mn><\/mml:math>). Pregnancy outcomes were comparable between groups. Among preterm live births, pregnancy duration was significantly longer in HCQ users (2.4 weeks (95% CI 1.0\u20133.8; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>)). <jats:italic>Conclusion<\/jats:italic>. HCQ use was associated with longer pregnancy duration in the vulnerable preterm birth population, underscoring the beneficial effect of HCQ use during pregnancy.<\/jats:p>","DOI":"10.1155\/2017\/2810202","type":"journal-article","created":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T18:31:02Z","timestamp":1513535462000},"page":"1-5","source":"Crossref","is-referenced-by-count":45,"title":["Hydroxychloroquine Use in Lupus Patients during Pregnancy Is Associated with Longer Pregnancy Duration in Preterm Births"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-6062","authenticated-orcid":true,"given":"S. J.","family":"Kroese","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. H.","family":"de Hair","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Limper","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"Lely","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8221-1669","authenticated-orcid":true,"given":"J. M.","family":"van Laar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. H. W. M.","family":"Derksen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D. E.","family":"Fritsch-Stork","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands"},{"name":"Medizinische Abteilung Hanusch Krankenhaus and Ludwig Boltzmann Institut f\u00fcr Osteologie, Heinrich-Collin-Stra\u00dfe 30, 1140 Vienna, Austria"},{"name":"Sigmund Freud PrivatUniversit\u00e4t Wien, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.012"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22159"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1191\/096120301678646137"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315591027"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"issue":"2","key":"6","first-page":"288","volume":"29","year":"2002","journal-title":"The Journal of Rheumatology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1191\/096120399680411272"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200201000-00028"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(99)70022-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3102\/10769986029004421"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.078"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2006.02.006"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.2.372"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03587"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12872"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.7.486"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.2.133"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2235"}],"updated-by":[{"DOI":"10.1155\/2022\/9783521","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000}}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2017\/2810202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2017\/2810202.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2017\/2810202.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T18:31:03Z","timestamp":1513535463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2017\/2810202\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":19,"alternative-id":["2810202","2810202"],"URL":"https:\/\/doi.org\/10.1155\/2017\/2810202","relation":{"corrigendum":[{"id-type":"doi","id":"10.1155\/2022\/9783521","asserted-by":"object"}]},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}