{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T20:27:49Z","timestamp":1749155269815,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"Purpose<\/jats:italic>. Long-term mitomycin C (MMC) effects on photorefractive keratectomy (PRK) were compared in simple myopic and astigmatic patients. Methods<\/jats:italic>. In this observational cohort study, subjects were selected based on preoperative and postoperative data collected from medical records; they were divided into simple myopia with\/without MMC and myopic astigmatism with\/without MMC groups. Haze, uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), subjective refraction, and K-reading were evaluated at 1-, 3-, 6-, and 12-month follow-ups.Results<\/jats:italic>. One hundred fifty-nine eyes of 80 subjects (34 women and 46 men; mean age, 26.81\u2009\u00b1\u20097.74 years; range, 18\u201353 years; spherical powers, \u22120.50 to \u22128.00\u2009DS; and cylindrical powers, \u22120.25 to \u22125.00\u2009DC) were enrolled. One year postoperatively, the simple myopia with\/without MMC groups showed no difference in UCVA (P<\/mml:mi>=<\/mml:mo>0.187<\/mml:mn><\/mml:math>), BCVA (P<\/mml:mi>=<\/mml:mo>0.163<\/mml:mn><\/mml:math>), or spherical equivalent (P<\/mml:mi>=<\/mml:mo>0.163<\/mml:mn><\/mml:math>) and a significant difference (P<\/mml:mi>=<\/mml:mo>0.0495<\/mml:mn><\/mml:math>) in K-reading; the haze formation difference was nonsignificant (P<\/mml:mi>=<\/mml:mo>0.056<\/mml:mn><\/mml:math>). Astigmatic groups with\/without MMC showed a significant difference in K-reading (P<\/mml:mi><<\/mml:mo>0.0001<\/mml:mn><\/mml:math>). MMC groups had less haze formation (P<\/mml:mi><<\/mml:mo>0.0001<\/mml:mn><\/mml:math>).Conclusion<\/jats:italic>. PRK with intraoperative MMC application showed excellent visual outcomes. MMC\u2019s effect on astigmatic patients was significantly better with acceptable safety and minimal side effects.<\/jats:p>","DOI":"10.1155\/2017\/2841408","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T17:01:36Z","timestamp":1489510896000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Mitomycin C on Myopic versus Astigmatic Photorefractive Keratectomy"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-0893","authenticated-orcid":true,"given":"Ashwag A.","family":"Almosa","sequence":"first","affiliation":[{"name":"College of Applied Medical Science, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samah M.","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ain Shams University, Ramses St., Abbasia, Cairo 191566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"year":"2002","key":"1"},{"year":"2007","key":"2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.11.013"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02463.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.03.029"},{"issue":"1","key":"6","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.3928\/1081597X-20080101-13","volume":"24","year":"2008","journal-title":"Journal of Refractive Surgery"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.01.019"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20140320-04"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/112067210601600206","volume":"16","year":"2006","journal-title":"European Journal of Ophthalmology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.07.035"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.07.020"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.321.8576"},{"issue":"12","key":"13","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/S0886-3350(02)01701-7","volume":"28","year":"2002","journal-title":"Journal of Cataract and Refractive Surgery"},{"issue":"3","key":"14","first-page":"142","volume":"4","year":"2009","journal-title":"Journal of Ophthalmic & Vision Research"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/2841408.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/2841408.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/2841408.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T14:37:02Z","timestamp":1568903822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2017\/2841408\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":14,"alternative-id":["2841408","2841408"],"URL":"https:\/\/doi.org\/10.1155\/2017\/2841408","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"type":"print","value":"2090-004X"},{"type":"electronic","value":"2090-0058"}],"subject":[],"published":{"date-parts":[[2017]]}}}