{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:03:19Z","timestamp":1759564999882,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004017","name":"Japanese Association of Dialysis Physicians","doi-asserted-by":"publisher","award":["27088","JKFB16-3"],"award-info":[{"award-number":["27088","JKFB16-3"]}],"id":[{"id":"10.13039\/501100004017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007638","name":"Kidney Foundation, Japan","doi-asserted-by":"publisher","award":["27088","JKFB16-3"],"award-info":[{"award-number":["27088","JKFB16-3"]}],"id":[{"id":"10.13039\/501100007638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Near-infrared spectroscopy revealed that the regional saturation of oxygen (rSO<jats:sub>2<\/jats:sub>) in cerebral tissue is lower in hemodialysis (HD) patients than in healthy subjects. However, no study has examined the changes in cerebral oxygenation by aortic arch calcification (AAC) progression in HD patients.<jats:italic> Methods<\/jats:italic>. A total of 104 HD patients were divided into four groups by AAC grade determined using chest radiography: 23 patients at grade 0, 24 at grade 1, 30 at grade 2, and 27 at grade 3. Differences in clinical parameters, including cerebral rSO<jats:sub>2<\/jats:sub>, among AAC grades were investigated and atherosclerotic parameters affecting cerebral rSO<jats:sub>2<\/jats:sub> values were identified.<jats:italic> Results<\/jats:italic>. Cerebral rSO<jats:sub>2<\/jats:sub> significantly decreased as AAC progressed (AAC grade 3 versus grade 0, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math> versus grade 1, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). Multivariate logistic regression analysis was performed using parameters with <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><\/mml:mrow><\/mml:math> values &lt; 0.20 in univariate analysis between cerebral rSO<jats:sub>2<\/jats:sub> values less than the mean and atherosclerotic parameters. AAC grades 2 and 3, serum phosphate level, and history of smoking were factors associated with the cerebral rSO<jats:sub>2<\/jats:sub> decrease.<jats:italic> Conclusions<\/jats:italic>. Cerebral rSO<jats:sub>2<\/jats:sub> significantly decreased as AAC progressed and was independently associated with higher AAC grade, serum phosphate level, and history of smoking.<\/jats:p>","DOI":"10.1155\/2017\/2852514","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T17:01:10Z","timestamp":1507050070000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Deterioration of Cerebral Oxygenation by Aortic Arch Calcification Progression in Patients Undergoing Hemodialysis: A Cross-Sectional Study"],"prefix":"10.1155","volume":"2017","author":[{"given":"Kiyonori","family":"Ito","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-3048","authenticated-orcid":true,"given":"Susumu","family":"Ookawara","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Okochi","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Ueda","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Kofuji","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Hayasaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhisa","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Yanai","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Kitano","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsutoshi","family":"Shindo","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Hirai","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Kaku","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Tabei","sequence":"additional","affiliation":[{"name":"Minami-Uonuma City Hospital, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Morishita","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"6","key":"1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/1744-9987.12281","volume":"18","year":"2014","journal-title":"Therapeutic Apheresis and Dialysis"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2014111118"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00351.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1159\/000328722"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.5551\/jat.E570"},{"issue":"3","key":"6","first-page":"233","volume":"21","year":"2002","journal-title":"International Angiology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.5551\/jat.22483"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.11.012"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.2.283"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000166974.96219.cd"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000630"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12303"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000246814.29362.f4"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.07.049"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1159\/000358432"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117474"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1139\/h04-031"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1586\/17434440.3.2.235"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0925"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.2.003047"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/35\/7\/1349"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1995.11740293"},{"journal-title":"ISRN Neurol","year":"2012","key":"23"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-012-0265-8"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/srep20303"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg414"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.234914"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.06.018"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1159\/000368476"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq582"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1159\/000347073"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.27421"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000080934.68280.82"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.11-96"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000081664.65772.EB"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-005-0341-3"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.232"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.03.027"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.138396"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.607"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2011.00560.x"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/2852514.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/2852514.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/2852514.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T17:01:16Z","timestamp":1507050076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/2852514\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":41,"alternative-id":["2852514","2852514"],"URL":"https:\/\/doi.org\/10.1155\/2017\/2852514","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2017]]}}}