{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:08:35Z","timestamp":1753884515398,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":72,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI15C3114"],"award-info":[{"award-number":["HI15C3114"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Functional dyspepsia (FD), a common upper gastrointestinal disease, is difficult to manage because of the limitations of current conventional treatments. Yukgunja\u2010tang (YGJT) is widely used to treat FD in clinical practice in Korea, Japan, and China. However, YGJT significantly improves few symptoms of FD. In Korean medicine, FD is a well\u2010known functional gastric disease that shows difference in the effect of herbal medicine depending on constitution or type of Korean medicine diagnosis. This study aims to investigate the efficacy of YGJT on FD patients classified by 3\u2010dimensional facial measurement using a 3\u2010dimensional facial shape diagnostic system (3\u2010FSDS). <jats:italic>Methods<\/jats:italic>. A placebo\u2010controlled, double\u2010blind, randomized, two\u2010center trial will be performed to evaluate the efficacy of YGJT on FD patients. Eligible subjects will be initially classified as two types by 3\u2010dimensional facial measurement using the 3\u2010FSDS. Ninety\u2010six subjects (48 subjects per each type) will be enrolled. These subjects will be randomly allocated into treatment or control groups in a 2\u2009:\u20091 ratio. YGJT or placebo will be administered to each group during the 8\u2010week treatment period. The primary outcome is total dyspepsia symptom scale, and the secondary outcomes include single dyspepsia symptom scale, proportion of responders with adequate symptom relief, visual analog scale, Nepean dyspepsia index\u2010Korean version, functional dyspepsia\u2010related quality of life, and spleen qi deficiency questionnaire. <jats:italic>Discussion<\/jats:italic>. This is the first randomized controlled trial to assess the efficacy of the YGJT on FD patients classified by 3\u2010dimensional facial measurement. We will compare the treatment effect of the YGJT on FD patients classified as two types using the 3\u2010FSDS. The results of this trial will help the FD patients improve the symptoms and quality of life effectively and provide objective evidence for prescribing the YGJT to FD patients in clinical practice. <jats:italic>Trial Registration<\/jats:italic>. This trial is registered with Clinical Research Information Service Identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/cris.nih.go.kr\/cris\/en\/search\/search_result_st01.jsp?seq=6988\">KCT0001920<\/jats:ext-link>, 15 May, 2016.<\/jats:p>","DOI":"10.1155\/2017\/2894507","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T21:06:31Z","timestamp":1489525591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of a Herbal Medicine, Yukgunja\u2010Tang, on Functional Dyspepsia Patients Classified by 3\u2010Dimensional Facial Measurement: A Study Protocol for Placebo\u2010Controlled, Double\u2010Blind, Randomized Trial"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2921-5163","authenticated-orcid":false,"given":"Juyeon","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-7317","authenticated-orcid":false,"given":"Jae-Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9902-0938","authenticated-orcid":false,"given":"Seok-Jae","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Hyung","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6572-3734","authenticated-orcid":false,"given":"Jong-Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inkwon","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2164-357X","authenticated-orcid":false,"given":"Jinsung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.14"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i17.2661"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2014.29.2.156"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05128.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640613499567"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001960.pub3"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02196.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/519035"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/936459"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/364260"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1993.tb00120.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01290.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0687-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep173"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01648.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2013.06.003"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-54"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12348"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.5754\/hge11246"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3803"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13074"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2012.0507"},{"key":"e_1_2_7_23_2","first-page":"540","article-title":"Study on diagnosis by facial shapes and sign as a disease-prediction data for a construction of the ante-disease pattern diagno-therapeutic system\u2014focusing on gallbladder\u2032s versus bladder\u2032s body and masculine versus feminine shape","volume":"23","author":"Kim J. 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