{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T20:56:32Z","timestamp":1763499392991,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":323,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2016R1C1B1012787"],"award-info":[{"award-number":["NRF-2016R1C1B1012787"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002465","name":"Daejeon University","doi-asserted-by":"publisher","award":["201503190001"],"award-info":[{"award-number":["201503190001"]}],"id":[{"id":"10.13039\/501100002465","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Precocious puberty is a common endocrine disease in children. Inappropriate activation of hypothalamic\u2013pituitary\u2013gonadal axis leads to the development of secondary sexual characteristics at an earlier age than normal children and causes short stature in adulthood. <jats:italic>Objectives<\/jats:italic>. The aim of this study is to evaluate the preventive effects of a herbal formulation containing a mixture of <jats:italic>Coicis Semen<\/jats:italic> and <jats:italic>Artemisia capillaris<\/jats:italic> (hEIF extract) on precocious puberty. <jats:italic>Methods<\/jats:italic>. The preventive effect of hEIF extract on precocious puberty in rats was evaluated by measuring blood component after 3 weeks of treatment via oral administration. Network pharmacological analyses were performed to predict the bioactive components of hEIF extract. <jats:italic>Results<\/jats:italic>. <jats:italic>In vivo<\/jats:italic> studies showed that hEIF extract significantly reduced follicle stimulating hormone (FSH) levels. After treatment with 200\u2009mg\/kg of hEIF extract, the FSH level was 5.33 \u00b1 1.10\u2009ng\/mL, whereas the FSH level in the vehicle group was 46.73 \u00b1 0.80\u2009ng\/mL. Moreover, the use of hEIF extract did not stimulate body growth and bone accretion in rats. The network pharmacological analysis led to the identification of multiple targets of hEIF extract related to lipolysis and the female sex hormone\u2010related pathways. <jats:italic>Conclusion<\/jats:italic>. hEIF extract can be used as an FSH inhibitor for the treatment of precocious puberty.<\/jats:p>","DOI":"10.1155\/2017\/2906014","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T23:30:38Z","timestamp":1511220638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of <i>Coicis Semen<\/i> and <i>Artemisia capillaris<\/i> for Precocious Puberty: A Preliminary Experimental Study Using Female Rats"],"prefix":"10.1155","volume":"2017","author":[{"given":"Tuy An","family":"Trinh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Chan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihong","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Eop","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2050-5244","authenticated-orcid":false,"given":"Ki Sung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3738-3239","authenticated-orcid":false,"given":"Hwa Seung","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7477-9991","authenticated-orcid":false,"given":"Hye Lim","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"215","article-title":"Recent advance in pathogenesis and treatment of precocious puberty","volume":"10","author":"Park M. 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