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CD154, the ligand of CD40, is a key mediator of inflammation. CD154 confers a proinflammatory phenotype to macrophages and controls several macrophagic functions. Here, we studied the contribution of CD154 in a mouse model of toxic liver injury with carbon tetrachloride and a model of absorbable suture graft. In both models, granulomas are triggered in response to endogenous persistent liver calcified necrotic lesions or by grafted sutures. CD154-deficient mice showed delayed clearance of carbon tetrachloride-induced liver calcified necrotic lesions and impaired progression of suture-induced granuloma. In vitro, CD154 stimulated phagocytosis of opsonized erythrocytes by macrophages, suggesting a potential mechanism for the altered granulomatous inflammation in CD154KO mice. These results suggest that CD154 may contribute to the natural history of granulomatous inflammation.<\/jats:p>","DOI":"10.1155\/2017\/2982879","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T21:02:27Z","timestamp":1499893347000},"page":"1-14","source":"Crossref","is-referenced-by-count":1,"title":["A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5430-1680","authenticated-orcid":true,"given":"Julien","family":"Villeneuve","sequence":"first","affiliation":[{"name":"Cell and Developmental Biology Department, Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Desmouli\u00e8re","sequence":"additional","affiliation":[{"name":"EA 6309 and Department of Physiology, Faculty of Pharmacy, University of Limoges, 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