{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:01:48Z","timestamp":1790373708088,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T00:00:00Z","timestamp":1506902400000},"content-version":"vor","delay-in-days":274,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy","award":["4945\/23\/08.03.2016"],"award-info":[{"award-number":["4945\/23\/08.03.2016"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Oxidative stress and inflammation can be involved in cognitive dysfunction associated with neurodegenerative disorders. Diazepam (DZP) administration has been chosen to simulate the memory impairment. The aim of this study was to evaluate the effects of curcumin (CUR) on spatial cognition, ambulatory activity, and blood and brain oxidative stress levels. The ERK\/NF\u2010<jats:italic>\u03ba<\/jats:italic>B signaling pathway and the histopathological changes in the hippocampus and frontal lobe, in diazepam\u2010treated rats, were also analyzed. The animals were divided into 4 groups: control, carboxymethylcellulose (CMC)\u2009+\u2009CUR, CMC\u2009+\u2009DZP, and CUR\u2009+\u2009CMC\u2009+\u2009DZP. CUR (150\u2009mg\/kg b.w.) was orally administered for 28 days. DZP (2\u2009mg\/kg b.w.) was intraperitoneally administered 20 minutes before the behavioral tests (open field test, Y\u2010maze, and elevated plus maze). CUR improved the spontaneous alternation behavior, decreased the oxidative stress levels, both in the blood and in the hippocampus, and downregulated the extracellular signal\u2010regulated kinase (ERK 1\/2)\/nuclear transcription factor\u2010 (NF\u2010) <jats:italic>\u03ba<\/jats:italic>B\/pNF\u2010<jats:italic>\u03ba<\/jats:italic>B pathway in the hippocampus and the iNOS expression in the hippocampus and frontal lobe of the DZP\u2010treated rats. Histopathologically, no microscopic changes were found. The immunohistochemical signal of iNOS decreased in the DZP and CUR\u2010treated group. Thus, our findings suggest that curcumin administration may improve the cognitive performance and may also have an antioxidant effect.<\/jats:p>","DOI":"10.1155\/2017\/3037876","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T21:01:20Z","timestamp":1506978080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Curcumin Reverses the Diazepam\u2010Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1\/2\/NF\u2010<i>\u03ba<\/i>B Pathway in Brain"],"prefix":"10.1155","volume":"2017","author":[{"given":"Alexandra C.","family":"Sevastre-Berghian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8425-8399","authenticated-orcid":false,"given":"Vlad","family":"F\u0103g\u0103r\u0103san","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad A.","family":"Toma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"B\u00e2ldea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Olteanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remus","family":"Moldovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoleta","family":"Decea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-4925","authenticated-orcid":false,"given":"Gabriela A.","family":"Filip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona V.","family":"Clichici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,2]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"22","article-title":"Nootropic efficacy of Euphorbia thymifolia Linn phytosterol on mice","volume":"5","author":"Bigoniya P.","year":"2015","journal-title":"International Journal of Phytotherapy"},{"key":"e_1_2_7_2_2","first-page":"112","article-title":"Comparison of the effects of different doses diazepam on learning and memory processes in rats using active and passive avoidance tests","volume":"5","author":"Dimitrova D.","year":"2015","journal-title":"Indian Journal of Pharmaceutical Science & Research"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-9668.117025"},{"key":"e_1_2_7_4_2","first-page":"1015","article-title":"Amelioration of diazepam induced memory impairment by fruit of Cucumis sativus L in aged mice by using animal models of Alzheimer\u2019s disease","volume":"6","author":"Kumar M.","year":"2015","journal-title":"International Journal of Pharmacy and Pharmaceutical Research"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.039"},{"key":"e_1_2_7_6_2","first-page":"1189","article-title":"Plant-derived neuroprotective agents in Parkinson\u2019s disease","volume":"7","author":"Fu W.","year":"2015","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.11.013"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1434"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20624"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0952-x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-4-8"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134156"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/10767"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5017460"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2012.02.008"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1516-93322008000400019"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.53.43"},{"key":"e_1_2_7_18_2","first-page":"214","article-title":"Benzodiazepine pharmacology and central nervous system-mediated effects","volume":"13","author":"Griffin C. 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