{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:24:31Z","timestamp":1774653871847,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501336"],"award-info":[{"award-number":["81501336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["201702156"],"award-info":[{"award-number":["201702156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"medical science and technology research project of Henan province","award":["81501336"],"award-info":[{"award-number":["81501336"]}]},{"name":"medical science and technology research project of Henan province","award":["201702156"],"award-info":[{"award-number":["201702156"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Congenital heart defect (CHD) is one of the most common birth defects in the world. The methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes are two of the most important candidate genes for fetal CHD. However, the correlations between the two genes and fetal CHD were inconsistent in various reports. Therefore, this study is aimed to evaluate the parental effects of the two genes on fetal CHD via three genetic polymorphisms, MTHFR 677C&gt;T (rs1801133), MTHFR 1298 A&gt;C (rs1801131), and MTRR 66A&gt;G (rs1801394).<jats:italic>Methods<\/jats:italic>. Parents with pregnancy history of fetal CHD were divided into two subgroups: ventricular septal defect (VSD) (21) and non-VSD groups (78). VSD, non-VSD, and 114 control parents (controls) were analyzed in this study. Genotyping of these genetic polymorphisms was done by sequencing.<jats:italic>Results<\/jats:italic>. The MTHFR 677C&gt;T polymorphism of either mothers or fathers was independently associated with fetal non-VSD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) but not VSD, while the MTRR 66A&gt;G polymorphism was independently associated with fetal VSD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) but not non-VSD. No significance was found for MTHFR 1298A&gt;C polymorphism.<jats:italic>Conclusion<\/jats:italic>. In either maternal or paternal group, the MTHFR 677C&gt;T polymorphism was independently related to fetal non-VSD, while the MTRR 66A&gt;G polymorphism was independently related to fetal VSD.<\/jats:p>","DOI":"10.1155\/2017\/3043476","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T17:02:48Z","timestamp":1499101368000},"page":"1-7","source":"Crossref","is-referenced-by-count":18,"title":["Parental Genetic Variants, MTHFR 677C&gt;T and MTRR 66A&gt;G, Associated Differently with Fetal Congenital Heart Defect"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4680-8868","authenticated-orcid":true,"given":"Qian-nan","family":"Guo","sequence":"first","affiliation":[{"name":"The Medical Genetic Center, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou 450000, China"},{"name":"Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information 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