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Besides inhibiting aromatase activity, EXE has multiple biological functions, such as antiproliferation, anti-inflammatory, and antioxidant activities which are all involved in hepatic fibrosis. Therefore, we investigated the role of EXE during the progress of hepatic fibrosis. The effect of EXE on liver injury and fibrosis were assessed in two hepatic fibrosis rat models, which were induced by either carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) or bile duct ligation (BDL). The influence of EXE treatment on activation and proliferation of primary rat hepatic stellate cells (HSCs) was observed<jats:italic>in vitro<\/jats:italic>. The results showed that EXE attenuated the liver fibrosis by decreasing the collagen deposition and<jats:italic>\u03b1<\/jats:italic>-SMA expression<jats:italic>in vivo<\/jats:italic>and inhibited the activation and proliferation of primary rat HSCs<jats:italic>in vitro<\/jats:italic>. Additionally, EXE promoted the secretion of antifibrotic and anti-inflammatory cytokine IL-10<jats:italic>in vivo<\/jats:italic>and in HSC-T6 culture media. In conclusion, our findings reveal a new function of EXE on hepatic fibrosis and prompted its latent application in liver fibrotic-related disease.<\/jats:p>","DOI":"10.1155\/2017\/3072745","type":"journal-article","created":{"date-parts":[[2017,12,10]],"date-time":"2017-12-10T18:30:55Z","timestamp":1512930655000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10"],"prefix":"10.1155","volume":"2017","author":[{"given":"Ya-Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Medical College of Fudan University, Shanghai 200032, China"},{"name":"State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, 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