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Ursodeoxycholic acid (UDCA) therapy is the most effective and approved treatment for PBC and leads to a favorable outcome in the vast majority of cases. Although the etiology of PBC has not yet been elucidated, human leukocyte antigen (HLA) class II alleles have been consistently associated with disease onset for decades. Individuals in different geographic regions of the world may have varying susceptibility alleles that reflect indigenous triggering antigens. In this review, we describe the influence of HLA alleles and other gene polymorphisms on PBC along with the results of genome-wide association studies (GWAS) on this disease.<\/jats:p>","DOI":"10.1155\/2017\/3073504","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T21:01:22Z","timestamp":1485982882000},"page":"1-6","source":"Crossref","is-referenced-by-count":17,"title":["Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-9654","authenticated-orcid":true,"given":"Satoru","family":"Joshita","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeji","family":"Umemura","sequence":"additional","affiliation":[{"name":"Department of 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