{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:26:54Z","timestamp":1783423614913,"version":"3.54.6"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PFCE-UASLP"},{"name":"PRODEP"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Introduction.<\/jats:italic>The inferior alveolar nerve block (IANB) is the most common anesthetic technique used on mandibular teeth during root canal treatment. Its success in the presence of preoperative inflammation is still controversial. The aim of this study was to evaluate the sensitivity, specificity, predictive values, and accuracy of three diagnostic tests used to predict IANB failure in symptomatic irreversible pulpitis (SIP).<jats:italic>Methodology.<\/jats:italic>A cross-sectional study was carried out on the mandibular molars of 53 patients with SIP. All patients received a single cartridge of mepivacaine 2% with 1\u2009:\u2009100000 epinephrine using the IANB technique. Three diagnostic clinical tests were performed to detect anesthetic failure. Anesthetic failure was defined as a positive painful response to any of the three tests. Sensitivity, specificity, predictive values, accuracy, and ROC curves were calculated and compared and significant differences were analyzed.<jats:italic>Results.<\/jats:italic>IANB failure was determined in 71.7% of the patients. The sensitivity scores for the three tests (lip numbness, the cold stimuli test, and responsiveness during endodontic access) were 0.03, 0.35, and 0.55, respectively, and the specificity score was determined as 1 for all of the tests. Clinically, none of the evaluated tests demonstrated a high enough accuracy (0.30, 0.53, and 0.68 for lip numbness, the cold stimuli test, and responsiveness during endodontic access, resp.). A comparison of the areas under the curve in the ROC analyses showed statistically significant differences between the three tests (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>).<jats:italic>Conclusion.<\/jats:italic>None of the analyzed tests demonstrated a high enough accuracy to be considered a reliable diagnostic tool for the prediction of anesthetic failure.<\/jats:p>","DOI":"10.1155\/2017\/3108940","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T17:03:30Z","timestamp":1497459810000},"page":"1-8","source":"Crossref","is-referenced-by-count":25,"title":["Sensitivity, Specificity, Predictive Values, and Accuracy of Three Diagnostic Tests to Predict Inferior Alveolar Nerve Blockade Failure in Symptomatic Irreversible Pulpitis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-1266","authenticated-orcid":true,"given":"Daniel","family":"Chavarr\u00eda-Bola\u00f1os","sequence":"first","affiliation":[{"name":"Facultad de Odontolog\u00eda, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rodr\u00edguez-Wong","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Noguera-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda, Universidad Latina de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Esparza-Villalpando","sequence":"additional","affiliation":[{"name":"Doctorado Institucional en Ingenier\u00eda y Ciencia de Materiales, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, SLP, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Montero-Aguilar","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2314-8465","authenticated-orcid":true,"given":"Amaury","family":"Pozos-Guill\u00e9n","sequence":"additional","affiliation":[{"name":"Laboratorio de Ciencias B\u00e1sicas, Facultad de Estomatolog\u00eda, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, SLP, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1999.tb00782.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2002.0298"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2344\/0003-3006-57.2.59"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572011000100004"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.10103.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2009.12.003"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12293"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12463"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2015.812"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201600663"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.07.001"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12236"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12099"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12157"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12283"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.12.003"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0312"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.06.012"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.11.047"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151516"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90835-2"},{"issue":"4","key":"22","first-page":"874","volume":"27","year":"2015","journal-title":"Journal of Ayub Medical College"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2014.02.013"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000147512.81966.ba"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2016.11.011"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6932"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"30","series-title":"147","volume-title":"Endodontic anesthesia","year":"2011"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.12.025"},{"issue":"2","key":"32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.15517\/ijds.v19i2.28143","volume":"19","year":"2017","journal-title":"Odovtos-International Journal of Dental Sciences"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(85)90095-7"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.30108.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.12.009"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.05.007"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.12.022"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2003.00024.x"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/365785"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2008.00955.x"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01754.x"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2013.0052"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9762864"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512467804"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1118\/1.4927260"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13949"},{"issue":"25","key":"47","first-page":"1","volume":"8","year":"2004","journal-title":"Health Technology Assessment"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1126\/science.253.5018.390"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1983.10477973"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2017\/3108940.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2017\/3108940.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2017\/3108940.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T22:59:57Z","timestamp":1569452397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/prm\/2017\/3108940\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":49,"alternative-id":["3108940","3108940"],"URL":"https:\/\/doi.org\/10.1155\/2017\/3108940","relation":{},"ISSN":["1203-6765","1918-1523"],"issn-type":[{"value":"1203-6765","type":"print"},{"value":"1918-1523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}