{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:22:16Z","timestamp":1762928536316,"version":"3.41.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005068","name":"Jimma University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005068","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Currently, antimalarial drug resistance poses a serious challenge. This stresses the need for newer antimalarial compounds.<jats:italic>Carica papaya<\/jats:italic>is used traditionally and showed<jats:italic>in vitro<\/jats:italic>antimalarial activity. This study attempted to evaluate<jats:italic>in vivo<\/jats:italic>antimalarial activity of<jats:italic>C. papaya<\/jats:italic>in mice.<jats:italic>Methods<\/jats:italic>.<jats:italic>In vivo<\/jats:italic>antimalarial activity of solvent fractions of the plant was carried out against early<jats:italic>P. berghei<\/jats:italic>infection in mice. Parasitemia, temperature, PCV, and body weight of mice were recorded. Windows SPSS version 16 (one-way ANOVA followed by Tukey\u2019s post hoc test) was used for data analysis.<jats:italic>Results<\/jats:italic>. The pet ether and chloroform fractions of<jats:italic>C. papaya<\/jats:italic>fruit rind and root produced a significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) chemosuppressive effect. A maximum parasite suppression of 61.78% was produced by pet ether fraction of<jats:italic>C. papaya<\/jats:italic>fruit rind in the highest dose (400\u2009mg\/kg\/day). Only 400\u2009mg\/kg\/day dose of chloroform fraction of<jats:italic>C. papaya<\/jats:italic>root exhibited a parasite suppression effect (48.11%). But, methanol fraction of the plant parts produced less chemosuppressive effect.<jats:italic>Conclusion<\/jats:italic>. Pet ether fraction of<jats:italic>C. papaya<\/jats:italic>fruit rind had the highest antimalarial activity and could be a potential source of lead compound. Further study should be done to show the chemical and metabolomic profile of active ingredients.<\/jats:p>","DOI":"10.1155\/2017\/3121050","type":"journal-article","created":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T23:31:13Z","timestamp":1513553473000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["<i>In Vivo<\/i>Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of<i>Carica papaya<\/i>Linn (Caricaceae) against<i>Plasmodium berghei<\/i>in Mice"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4170-922X","authenticated-orcid":true,"given":"Gemechu","family":"Zeleke","sequence":"first","affiliation":[{"name":"Pharmacology Course Team, School of Pharmacy, Jimma University, P.O. Box 378, Jimma, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dereje","family":"Kebebe","sequence":"additional","affiliation":[{"name":"Pharmaceutics Course Team, School of Pharmacy, Jimma University, P.O. Box 378, Jimma, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eshetu","family":"Mulisa","sequence":"additional","affiliation":[{"name":"Pharmacology Course Team, School of Pharmacy, Jimma University, P.O. Box 378, Jimma, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanta","family":"Gashe","sequence":"additional","affiliation":[{"name":"Pharmaceutics Course Team, School of Pharmacy, Jimma University, P.O. 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