{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:11:40Z","timestamp":1767773500248,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005609","name":"University of Turku","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011797","name":"Turku University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011797","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u00c5bo Akademi University"},{"name":"Turku University Foundation"},{"name":"Foundation of Rauno and Anne Puolimatka"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. This study evaluated the potential of<jats:sup>68<\/jats:sup>Ga-citrate positron emission tomography\/computed tomography (PET\/CT) for the detection of infectious foci in patients with<jats:italic>Staphylococcus aureus<\/jats:italic>bacteraemia by comparing it with 2-[<jats:sup>18<\/jats:sup>F]fluoro-2-deoxy-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>D<\/mml:mi><\/mml:mrow><\/mml:math>-glucose (<jats:sup>18<\/jats:sup>F-FDG) PET\/CT.<jats:italic>Methods.<\/jats:italic>Four patients admitted to hospital due to<jats:italic>S. aureus<\/jats:italic>bacteraemia underwent both<jats:sup>18<\/jats:sup>F-FDG and<jats:sup>68<\/jats:sup>Ga-citrate whole-body PET\/CT scans to detect infectious foci.<jats:italic>Results.<\/jats:italic>The time from hospital admission and the initiation of antibiotic treatment to the first PET\/CT was 4\u201310 days. The time interval between<jats:sup>18<\/jats:sup>F-FDG and<jats:sup>68<\/jats:sup>Ga-citrate PET\/CT was 1\u20134 days. Three patients had vertebral osteomyelitis (spondylodiscitis) and one had osteomyelitis in the toe; these were detected by both<jats:sup>18<\/jats:sup>F-FDG (maximum standardised uptake value [<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">U<\/mml:mi><mml:mi mathvariant=\"normal\">V<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">m<\/mml:mi><mml:mi mathvariant=\"normal\">a<\/mml:mi><mml:mi mathvariant=\"normal\">x<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>]<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn fontstyle=\"italic\">6.0<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">1.0<\/mml:mn><\/mml:math>) and<jats:sup>68<\/jats:sup>Ga-citrate (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">U<\/mml:mi><mml:mi mathvariant=\"normal\">V<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">m<\/mml:mi><mml:mi mathvariant=\"normal\">a<\/mml:mi><mml:mi mathvariant=\"normal\">x<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>\u2009\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn fontstyle=\"italic\">6.8<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">3.5<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.61<\/mml:mn><\/mml:math>). Three patients had soft tissue infectious foci, with more intense<jats:sup>18<\/jats:sup>F-FDG uptake (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">U<\/mml:mi><mml:mi mathvariant=\"normal\">V<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">m<\/mml:mi><mml:mi mathvariant=\"normal\">a<\/mml:mi><mml:mi mathvariant=\"normal\">x<\/mml:mi><\/mml:mrow><\/mml:msub><mml:mo>\u2009<\/mml:mo><mml:mo>\u2009<\/mml:mo><mml:mn fontstyle=\"italic\">6.5<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">2.5<\/mml:mn><\/mml:math>) than<jats:sup>68<\/jats:sup>Ga-citrate uptake (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">U<\/mml:mi><mml:mi mathvariant=\"normal\">V<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">m<\/mml:mi><mml:mi mathvariant=\"normal\">a<\/mml:mi><mml:mi mathvariant=\"normal\">x<\/mml:mi><\/mml:mrow><\/mml:msub><mml:mo>\u2009<\/mml:mo><mml:mo>\u2009<\/mml:mo><mml:mn fontstyle=\"italic\">3.9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">1.2<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0033<\/mml:mn><\/mml:math>).<jats:italic>Conclusions.<\/jats:italic>Our small cohort of patients with<jats:italic>S. aureus<\/jats:italic>bacteraemia revealed that<jats:sup>68<\/jats:sup>Ga-citrate PET\/CT is comparable to<jats:sup>18<\/jats:sup>F-FDG PET\/CT for detection of osteomyelitis, whereas<jats:sup>18<\/jats:sup>F-FDG resulted in a higher signal for the detection of soft tissue infectious foci.<\/jats:p>","DOI":"10.1155\/2017\/3179607","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T23:30:35Z","timestamp":1508283035000},"page":"1-8","source":"Crossref","is-referenced-by-count":18,"title":["Head-to-Head Comparison of<sup>68<\/sup>Ga-Citrate and<sup>18<\/sup>F-FDG PET\/CT for Detection of Infectious Foci in Patients with<i>Staphylococcus aureus<\/i>Bacteraemia"],"prefix":"10.1155","volume":"2017","author":[{"given":"Soile P.","family":"Salom\u00e4ki","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Division of Medicine, Turku University Hospital, Turku, Finland"},{"name":"Turku PET Centre, University of Turku, Turku, Finland"},{"name":"Faculty of Medicine, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Kemppainen","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"},{"name":"Turku PET Centre, Turku University Hospital, Turku, Finland"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Hohenthal","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Division of Medicine, Turku University Hospital, Turku, Finland"},{"name":"Faculty of Medicine, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauliina","family":"Luoto","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli","family":"Eskola","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirjo","family":"Nuutila","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"},{"name":"Faculty of Medicine, University of Turku, Turku, Finland"},{"name":"Department of Endocrinology, Division of Medicine, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Sepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"},{"name":"Turku PET Centre, Turku University Hospital, Turku, Finland"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Piril\u00e4","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Turku, Turku, Finland"},{"name":"Department of Rheumatology, Division of Medicine, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarmo","family":"Oksi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Division of Medicine, Turku University Hospital, Turku, Finland"},{"name":"Faculty of Medicine, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-7977","authenticated-orcid":true,"given":"Anne","family":"Roivainen","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"},{"name":"Turku PET Centre, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4274\/MIRT.20.04","volume":"20","year":"2011","journal-title":"Molecular Imaging and Radionuclide Therapy"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31824d7ed2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.072371"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.080184"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2174\/1874471011205010071"},{"key":"6","first-page":"88","volume":"26","year":"1985","journal-title":"Journal of Nuclear Medicine"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2010.09.011"},{"key":"8","first-page":"282","volume":"21","year":"1980","journal-title":"Journal of Nuclear Medicine"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1841-9"},{"key":"10","first-page":"169","volume":"5","year":"2015","journal-title":"American Journal of Nuclear Medicine and Molecular Imaging"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ482"},{"key":"12","first-page":"105","volume-title":"Complicating infectious foci in patients with Staphylococcus aureus or Streptococcus species bacteraemia","volume":"26","year":"2007"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/2191-219X-1-14"},{"key":"14","first-page":"523","volume":"28","year":"2014","journal-title":"Annals of Nuclear Medicine"}],"container-title":["Contrast Media &amp; Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2017\/3179607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2017\/3179607.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2017\/3179607.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T10:51:05Z","timestamp":1589799065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmi\/2017\/3179607\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":14,"alternative-id":["3179607","3179607"],"URL":"https:\/\/doi.org\/10.1155\/2017\/3179607","relation":{},"ISSN":["1555-4309","1555-4317"],"issn-type":[{"type":"print","value":"1555-4309"},{"type":"electronic","value":"1555-4317"}],"subject":[],"published":{"date-parts":[[2017]]}}}