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common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens\u2013Johnson syndrome (SJS)\/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs have been shown to have significant associations with specific alleles of human leukocyte antigen (HLA) genes. For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of<jats:italic>HLA-B<\/jats:italic>gene (terms<jats:italic>HLA-B<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msup><mml:mrow\/><mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math><jats:italic>57:01<\/jats:italic>). The incidences of abacavir hypersensitivity are much higher in Caucasians compared to other populations due to various allele frequencies in different ethnic populations. The antithyroid drug- (ATDs- ) induced agranulocytosis are strongly associated with two alleles:<jats:italic>HLA-B<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msup><mml:mrow\/><mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math><jats:italic>38:02<\/jats:italic>and<jats:italic>HLA-DRB1<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:msup><mml:mrow\/><mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math><jats:italic>08:03<\/jats:italic>. In addition,<jats:italic>HLA-B<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:msup><mml:mrow\/><mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math><jats:italic>15:02<\/jats:italic>allele was reported to be related to carbamazepine-induced SJS\/TEN, and<jats:italic>HLA-B<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:msup><mml:mrow\/><mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math><jats:italic>57:01<\/jats:italic>in abacavir hypersensitivity and flucloxacillin induced drug-induced liver injury (DILI). In this review, we summarized the alleles of HLA genes which have been proposed to have association with ADRs caused by different drugs.<\/jats:p>","DOI":"10.1155\/2017\/3186328","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T23:30:32Z","timestamp":1511479832000},"page":"1-10","source":"Crossref","is-referenced-by-count":119,"title":["HLA Association with Drug-Induced Adverse Reactions"],"prefix":"10.1155","volume":"2017","author":[{"given":"Wen-Lang","family":"Fan","sequence":"first","affiliation":[{"name":"Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan"},{"name":"Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Shin","family":"Shiao","sequence":"additional","affiliation":[{"name":"Research Center, Faculty of Medicine Ramathibodi Hospital, 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