{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:31:35Z","timestamp":1773336695086,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Urology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To compare the structure of the testis in fetuses with prune belly syndrome (PBS) to normal controls.<jats:italic>Materials and Methods<\/jats:italic>. We studied 6 testes obtained from 3 fetuses with PBS and 14 testes from 7 male fetuses. The testicular specimens were cut into 5-<jats:italic>\u03bc<\/jats:italic>m thick sections and stained with hematoxylin and eosin (HE), to observe the seminiferous tubules; Weigert\u2019s solution to observe elastic fibers; and picrosirius red to observe collagen. The images were captured with an Olympus BX51 microscope and Olympus DP70 camera. The stereological analysis was done with the Image Pro and Image J programs. Means were statistically compared using the Mann\u2013Whitney<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>U<\/mml:mi><\/mml:mrow><\/mml:math>test (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.005<\/mml:mn><\/mml:math>).<jats:italic>Results<\/jats:italic>. Quantitative analysis documented no differences (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.4<\/mml:mn><\/mml:math>) in number of seminiferous tubules (ST) in PBS testes (mean = 8.87%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">D<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">1.59<\/mml:mn><\/mml:math>), when compared to the control (mean = 11.4%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">D<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">2.99<\/mml:mn><\/mml:math>) and no differences (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.8<\/mml:mn><\/mml:math>) in diameter of ST in PBS testes (mean = 52.85\u2009<jats:italic>\u03bc<\/jats:italic>m,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">D<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">1.58<\/mml:mn><\/mml:math>) when compared to the control group (mean = 53.17\u2009<jats:italic>\u03bc<\/jats:italic>m,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">D<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">1.55<\/mml:mn><\/mml:math>), but we did observe a lower number (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0002<\/mml:mn><\/mml:math>) of Leydig cells in the PBS testes (mean = 67.03% and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">D<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">3.697<\/mml:mn><\/mml:math>) when compared to the control group (mean = 90.1% and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">D<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">2.986<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Our study showed a lower concentration of Leydig cells in the triad syndrome fetuses.<\/jats:p>","DOI":"10.1155\/2017\/3254980","type":"journal-article","created":{"date-parts":[[2017,5,21]],"date-time":"2017-05-21T17:01:04Z","timestamp":1495386064000},"page":"1-5","source":"Crossref","is-referenced-by-count":9,"title":["Study of Testicular Structure in Fetuses with Prune Belly Syndrome"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1562-6068","authenticated-orcid":true,"given":"Luciano A.","family":"Favorito","sequence":"first","affiliation":[{"name":"Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suelen F.","family":"Costa","sequence":"additional","affiliation":[{"name":"Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar S.","family":"Costa","sequence":"additional","affiliation":[{"name":"Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Vieiralves","sequence":"additional","affiliation":[{"name":"Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio O.","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J. 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