{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:56:46Z","timestamp":1774943806459,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630012"],"award-info":[{"award-number":["81630012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570385"],"award-info":[{"award-number":["81570385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370363"],"award-info":[{"award-number":["81370363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2014LX04"],"award-info":[{"award-number":["2014LX04"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2012028"],"award-info":[{"award-number":["2012028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630012"],"award-info":[{"award-number":["81630012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570385"],"award-info":[{"award-number":["81570385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370363"],"award-info":[{"award-number":["81370363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2014LX04"],"award-info":[{"award-number":["2014LX04"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2012028"],"award-info":[{"award-number":["2012028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630012"],"award-info":[{"award-number":["81630012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570385"],"award-info":[{"award-number":["81570385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370363"],"award-info":[{"award-number":["81370363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2014LX04"],"award-info":[{"award-number":["2014LX04"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2012028"],"award-info":[{"award-number":["2012028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Leading Medical Cooperation Project of Songjiang District","award":["81630012"],"award-info":[{"award-number":["81630012"]}]},{"name":"Leading Medical Cooperation Project of Songjiang District","award":["81570385"],"award-info":[{"award-number":["81570385"]}]},{"name":"Leading Medical Cooperation Project of Songjiang District","award":["81370363"],"award-info":[{"award-number":["81370363"]}]},{"name":"Leading Medical Cooperation Project of Songjiang District","award":["2014LX04"],"award-info":[{"award-number":["2014LX04"]}]},{"name":"Leading Medical Cooperation Project of Songjiang District","award":["2012028"],"award-info":[{"award-number":["2012028"]}]},{"name":"Leading Medical Cooperation Project of Songjiang District","award":["81630012"],"award-info":[{"award-number":["81630012"]}]},{"name":"Leading Medical Cooperation Project of Songjiang District","award":["81570385"],"award-info":[{"award-number":["81570385"]}]},{"name":"Leading Medical Cooperation Project of Songjiang District","award":["81370363"],"award-info":[{"award-number":["81370363"]}]},{"name":"Leading Medical Cooperation Project of Songjiang District","award":["2014LX04"],"award-info":[{"award-number":["2014LX04"]}]},{"name":"Leading Medical Cooperation Project of Songjiang District","award":["2012028"],"award-info":[{"award-number":["2012028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>It has been demonstrated that homocysteine (HCY) is a significant risk factor of hypertension, which is characterized by overactivity of sympathetic tone. Excessive oxidative stress in the rostral ventrolateral medulla (RVLM), a key region for control of sympathetic outflow, contributes to sympathetic hyperactivity in hypertension. Therefore, the goal of the present study is to determine the effect of systemic HCY on production of reactive oxygen species (ROS) in the RVLM. In the rat model of the diet-induced hyperhomocysteinemia (L-methionine, 1\u2009g\/kg\/day, 8 weeks), we found that the HCY resulted in a significant increase (\u22483.7-fold, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) in ROS production in the RVLM, which was paralleled with enhanced sympathetic tone and blood pressure (BP). Compared to the vehicle group, levels of BP and basal renal sympathetic nerve activity in the HCY group were significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>5<\/mml:mn><\/mml:math>) increased by an average of 27\u2009mmHg and 31%, respectively. Furthermore, the rats treated with L-methionine (1\u2009g\/kg\/day, 8 weeks) showed an upregulation of NADPHase (NOX4) protein expression and a downregulation of superoxide dismutase protein expression in the RVLM. The current data suggest that central oxidative stress induced by systemic HCY plays an important role in hypertension-associated sympathetic overactivity.<\/jats:p>","DOI":"10.1155\/2017\/3256325","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T17:00:09Z","timestamp":1506704409000},"page":"1-7","source":"Crossref","is-referenced-by-count":10,"title":["The Cardiovascular Effect of Systemic Homocysteine Is Associated with Oxidative Stress in the Rostral Ventrolateral Medulla"],"prefix":"10.1155","volume":"2017","author":[{"given":"Mei-Fang","family":"Zhong","sequence":"first","affiliation":[{"name":"Medical Training Center of Songjiang District, Shanghai 201620, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sijing Hospital, Shanghai 201601, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nursing, Wuxi Higher Health Vocational Technology School, Wuxi 214028, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Center of Polar Medical Research, Second Military Medical University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang-Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Center of Polar Medical Research, Second Military Medical University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-4505","authenticated-orcid":true,"given":"Wei-Zhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Center of Polar Medical Research, Second Military Medical University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuw027"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.238485"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1024\/0040-5930.62.9.641"},{"key":"4","first-page":"1242","volume":"7","year":"2001","journal-title":"Medical Science Monitor"},{"key":"5","first-page":"63","volume":"7","year":"2011","journal-title":"ARYA Atherosclerosis"},{"key":"6","first-page":"39","volume":"84","year":"2006","journal-title":"Klinicheskaia Meditsina"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2174\/092986710791959783"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2004.09.007"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2017.01.003"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07792"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-010-0100-z"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011.14"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32830dd5d3"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7413963"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.12.001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-016-9688-2"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2010.10719810"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000028489.29543.58"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12065"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01273.2009"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00518.2013"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000887"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2158971"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.115600"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00205"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/847172"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-013-1651-5"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.5455\/msm.2015.27.95-98"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-27302012000500002"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140715074"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2013.10.006"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.04940.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00619.2003"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834e1df4"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.2075"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2016.11.013"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.06.021"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00391"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0340"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00187.2016"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.10.003"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-212"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.04.044"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083813"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-016-0723-z"}],"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2017\/3256325.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2017\/3256325.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2017\/3256325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T17:00:15Z","timestamp":1506704415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/np\/2017\/3256325\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":45,"alternative-id":["3256325","3256325"],"URL":"https:\/\/doi.org\/10.1155\/2017\/3256325","relation":{},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"value":"2090-5904","type":"print"},{"value":"1687-5443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}