{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:58:43Z","timestamp":1767772723720,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background\/Aims<\/jats:italic>. Recent evidence has suggested that appendix plays a pivotal role in the development and preservation of intestinal immune system. The aim of this study is to examine whether prior appendectomy is associated with an increased risk for the development of antibiotic-resistant bacteria in bacteremia from biliary tract infection (BTI).<jats:italic> Methods<\/jats:italic>. Charts from 174 consecutive cases of bacteremia derived from BTI were retrospectively reviewed. Using multivariate analysis, independent risk factors for development of antibiotic-resistant bacteria were identified among the clinical parameters, including a history of appendectomy.<jats:italic> Results<\/jats:italic>. In total, 221 bacteria strains were identified from 174 BTI events. Of those, 42 antibiotic-resistant bacteria were identified in 34 patients. Multivariate analysis revealed that prior appendectomy (Odds ratio (OR), 3.02; 95% confidence interval (CI), 1.15\u20137.87; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn fontstyle=\"italic\">26<\/mml:mn><\/mml:math>), antibiotic use within the preceding three months (OR, 3.06; 95% CI, 1.26\u20137.64; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn fontstyle=\"italic\">13<\/mml:mn><\/mml:math>), and bilioenteric anastomosis or sphincterotomy (OR, 3.77; 95% CI, 1.51\u20139.66; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.00<\/mml:mn><mml:mn fontstyle=\"italic\">46<\/mml:mn><\/mml:math>) were independent risk factors for antibiotic-resistant bacteria.<jats:italic> Conclusions<\/jats:italic>. Prior appendectomy was an independent risk factor for the development of antibiotic-resistant bacteria in bacteremia from BTI.<\/jats:p>","DOI":"10.1155\/2017\/3276120","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T17:01:10Z","timestamp":1494867670000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Appendectomy as a Risk Factor for Bacteremic Biliary Tract Infection Caused by Antibiotic-Resistant Pathogens"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6235-7994","authenticated-orcid":true,"given":"Koki","family":"Kawanishi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Wakayama Rosai Hospital, 93-1 Kinomoto, Wakayama City, Wakayama 640-8505, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wakayama Rosai Hospital, 93-1 Kinomoto, Wakayama City, Wakayama 640-8505, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wakayama Rosai Hospital, 93-1 Kinomoto, Wakayama City, Wakayama 640-8505, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuhiro","family":"Kakimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wakayama Rosai Hospital, 93-1 Kinomoto, Wakayama City, Wakayama 640-8505, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wakayama Rosai Hospital, 93-1 Kinomoto, Wakayama City, Wakayama 640-8505, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wakayama Rosai Hospital, 93-1 Kinomoto, Wakayama City, Wakayama 640-8505, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1869-2135","authenticated-orcid":true,"given":"Jun","family":"Kato","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Wakayama Medical University, 811 Kimiidera, Wakayama City, Wakayama 641-0012, 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