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Cachexia is prevalent in roughly 80% of cancer patients and accounts for up to 20% of all cancer\u2010related deaths. Proinflammatory cytokines IL\u20106, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and TGF\u2010<jats:italic>\u03b2<\/jats:italic> have been widely examined for their regulation of cancer cachexia. An established characteristic of cachectic skeletal muscle is a disrupted capacity for oxidative metabolism, which is thought to contribute to cancer patient fatigue, diminished metabolic function, and muscle mass loss. This review\u2019s primary objective is to highlight emerging evidence linking cancer\u2010induced inflammation to the dysfunctional regulation of mitochondrial dynamics, mitophagy, and biogenesis in cachectic muscle. 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