{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T20:16:15Z","timestamp":1775679375261,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National High Technology Research and Development Program of China","award":["2015AAO20511"],"award-info":[{"award-number":["2015AAO20511"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients.<jats:italic>Method<\/jats:italic>. A retrospective study of patients aged\u2009\u2265\u200945 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed within subgroups (age 45\u201365 years and age\u2009\u2265\u200965 years).<jats:italic>Results<\/jats:italic>. 76 patients (99 eyes) were included, of which 58% were females. The mean age at presentation was 55.53\u2009\u00b1\u20098.29 years (range: 45\u201383 years). Vision loss was severe at presentation, with initial best corrected vision activity (BCVA)\u2009&lt;\u200920\/200 in 93% and final BCVA\u2009&lt;\u200920\/200 in 53% of patients at 5-year follow-up. Final BCVA significantly correlated with the initial BCVA and peripapillary retinal nerve fiber layer. At last follow-up, 14.5% were diagnosed with neuromyelitis optica spectrum disorder (NMOSD), 1.3% were diagnosed with multiple sclerosis (MS), 5.2% with chronic relapsing inflammatory optic neuropathy, 1.3% with infectious ON, and 19.7% with autoimmune ON. None of the elderly group (\u226565 years) developed NMOSD or MS.<jats:italic>Conclusion<\/jats:italic>. Chinese patients in the age group\u2009\u2265\u200965 years with ON are less likely to develop NMOSD or MS. Notwithstanding, they had more severe visual loss at onset and poor recovery.<\/jats:p>","DOI":"10.1155\/2017\/3458356","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T18:30:44Z","timestamp":1513017044000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study"],"prefix":"10.1155","volume":"2017","author":[{"given":"Junqing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanfen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China"},{"name":"Department of Ophthalmology, The First Affiliated Hospital of Chinese People\u2019s Liberation Army General Hospital, Beijing, 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