{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:47:19Z","timestamp":1787017639917,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371387"],"award-info":[{"award-number":["81371387"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . The correlation between platelet function and recurrent ischemic stroke or TIA remains uncertain.\n                    <jats:italic>Objective<\/jats:italic>\n                    . To investigate two inductive agents to detect platelet functions and assess associations with recurrent ischemic stroke\/TIA.\n                    <jats:italic>Method<\/jats:italic>\n                    . The study included 738 ischemic stroke\/TIA patients. On days 0, 3, and 9 after antiplatelet therapy, platelet function tests were determined by maximum aggregation rate (MAR) using a PL-11 platelet function analyzer and phase matching reagents. Two induction agents were used: arachidonic acid (AA) and adenosine diphosphate (ADP). At 3-month follow-up, recurrence of stroke\/TIA was recorded.\n                    <jats:italic>Result<\/jats:italic>\n                    . Cut-off values of adequate platelet function inhibition were MAR\n                    <jats:sub>ADP<\/jats:sub>\n                    &lt; 35% and MAR\n                    <jats:sub>AA<\/jats:sub>\n                    &lt; 35%. Data showed that antiplatelet therapy could reduce the maximum aggregation rate. More importantly, adequate platelet function inhibition of either MAR\n                    <jats:sub>ADP<\/jats:sub>\n                    or MAR\n                    <jats:sub>AA<\/jats:sub>\n                    was not associated with the recurrence of stroke\/TIA, but adequate platelet function inhibition of not only MAR\n                    <jats:sub>ADP<\/jats:sub>\n                    but also MAR\n                    <jats:sub>AA<\/jats:sub>\n                    predicts lower recurrence (0\/121 (0.00%) versus 18\/459 (3.92%),\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0188).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The platelet function tested by PL-11 demonstrated that adequate inhibition of both MAR\n                    <jats:sub>ADP<\/jats:sub>\n                    and MAR\n                    <jats:sub>AA<\/jats:sub>\n                    could predict lower risk of ischemic stroke\/TIA recurrence.\n                  <\/jats:p>","DOI":"10.1155\/2017\/3504950","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T17:02:41Z","timestamp":1503594161000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Adequate Platelet Function Inhibition Confirmed by Two Inductive Agents Predicts Lower Recurrence of Ischemic Stroke\/Transient Ischemic Attack"],"prefix":"10.1155","volume":"2017","author":[{"given":"Lulu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juehua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongru","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiren","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated 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